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Erik Sedlak

Explore the profile of Erik Sedlak including associated specialties, affiliations and a list of published articles. Areas
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Articles 71
Citations 533
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Recent Articles
1.
Hovan A, Gala M, Sedlakova D, Bano G, Lee O, Zoldak G, et al.
Biophys Chem . 2024 Oct; 316:107333. PMID: 39413722
Flavin cofactors, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), as a part of flavoenzymes play a critical role in the catalysis of multiple reactions predominantly of a redox nature....
2.
Hovan A, Sedlakova D, Lee O, Bano G, Sedlak E
RSC Adv . 2024 Sep; 14(39):28783-28790. PMID: 39263436
Flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) are frequently used interchangeably in the catalysis of various reactions as part of flavoenzymes because they have the same functional component, the...
3.
Felcikova K, Hovan A, Polak M, Loginov D, Holotova V, Diaz C, et al.
Protein Sci . 2024 Mar; 33(4):e4921. PMID: 38501448
Flavin mononucleotide (FMN) is a highly efficient photosensitizer (PS) yielding singlet oxygen ( O ). However, its O production efficiency significantly decreases upon isoalloxazine ring encapsulation into the protein matrix...
4.
Hovanova V, Hovan A, Humenik M, Sedlak E
Protein Sci . 2023 Nov; 32(12):e4832. PMID: 37937854
Recombinant core spidroin eADF4(C16) has received increasing attention due to its ability to form micro- and nano-structured scaffolds, which are based on nanofibrils with great potential for biomedical and biotechnological...
5.
Hovanova V, Hovan A, Zoldak G, Sedlak E, Humenik M
Protein Sci . 2023 Jul; 32(8):e4722. PMID: 37417849
Recombinant spider silk proteins can be prepared in scalable fermentation processes and have been proven as sources of biomaterials for biomedical and technical applications. Nanofibrils, formed through the self-assembly of...
6.
Toul M, Slonkova V, Mican J, Urminsky A, Tomkova M, Sedlak E, et al.
Biotechnol Adv . 2023 May; 66:108174. PMID: 37182613
Cardiovascular diseases, such as myocardial infarction, ischemic stroke, and pulmonary embolism, are the most common causes of disability and death worldwide. Blood clot hydrolysis by thrombolytic enzymes and thrombectomy are...
7.
Dzupponova V, Tomaskova N, Antosova A, Sedlak E, Zoldak G
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047761
Thermophilic proteins and enzymes are attractive for use in industrial applications due to their resistance against heat and denaturants. Here, we report on a thermophilic protein that is stable at...
8.
Nemergut M, Sedlakova D, Fabriciova G, Belej D, Jancura D, Sedlak E
Int J Biol Macromol . 2023 Jan; 232:123379. PMID: 36702231
Thermal denaturation of human serum albumin has been the subject of many studies in recent decades, but the results of these studies are often conflicting and inconclusive. To clarify this,...
9.
Dusekova E, Garajova K, Yavaser R, Tomkova M, Sedlakova D, Dzurillova V, et al.
Biophys Chem . 2022 Jul; 288:106856. PMID: 35872468
Specific salts effect is well-known on stability and solubility of proteins, however, relatively limited knowledge is known regarding the effect on catalytic properties of enzymes. Here, we examined the effect...
10.
Hovan A, Sedlakova D, Berta M, Bano G, Sedlak E
Phys Chem Chem Phys . 2022 May; 24(21):13317-13324. PMID: 35608043
Singlet oxygen refers to the nonradical metastable excited state of molecular oxygen that readily oxidizes various cellular components. Its behavior in different biological systems has been studied for many years....