Erik L de Graaf
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Explore the profile of Erik L de Graaf including associated specialties, affiliations and a list of published articles.
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22
Citations
591
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Recent Articles
1.
Debets D, de Graaf E, Liefaard M, Sonke G, Lips E, Ressa A, et al.
iScience
. 2024 May;
27(6):109858.
PMID: 38784015
In this study, we measured the kinase activity profiles of 32 pre-treatment tumor biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential...
2.
Veth T, Kannegieter N, de Graaf E, Ruijtenbeek R, Joore J, Ressa A, et al.
Drug Discov Today
. 2024 Feb;
29(3):103907.
PMID: 38301799
The development of protein kinase inhibitors (PKIs) has gained significance owing to their therapeutic potential for diseases like cancer. In addition, there has been a rise in refining kinase activity...
3.
de Graaf E, Larsen M, van der Bolt N, Visser R, Verhagen O, Hipgrave Ederveen A, et al.
Immunology
. 2023 Dec;
171(3):428-439.
PMID: 38097893
The type and strength of effector functions mediated by immunoglobulin G (IgG) antibodies rely on the subclass and the composition of the N297 glycan. Glycosylation analysis of both bulk and...
4.
Szittner Z, Bentlage A, Temming A, Schmidt D, Visser R, Lissenberg-Thunnissen S, et al.
Front Immunol
. 2023 Oct;
14:1225603.
PMID: 37868955
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a...
5.
Fabro F, Kannegieter N, de Graaf E, Queiroz K, Lamfers M, Ressa A, et al.
Front Oncol
. 2022 Nov;
12:1012236.
PMID: 36408180
Glioblastoma is the deadliest brain cancer. One of the main reasons for poor outcome resides in therapy resistance, which adds additional challenges in finding an effective treatment. Small protein kinase...
6.
Larsen M, de Graaf E, Sonneveld M, Plomp H, Nouta J, Hoepel W, et al.
Science
. 2020 Dec;
371(6532).
PMID: 33361116
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential for IgG function, shows variable composition in...
7.
Wojcik I, Senard T, de Graaf E, Janssen G, de Ru A, Mohammed Y, et al.
Anal Chem
. 2020 Sep;
92(19):13172-13181.
PMID: 32886488
Fc gamma receptors (FcγRs) translate antigen recognition by immunoglobulin G (IgG) into various immune responses. A better understanding of this key element of immunity promises novel insights into mechanisms of...
8.
Temming A, de Taeye S, de Graaf E, de Neef L, Dekkers G, Bruggeman C, et al.
J Immunol
. 2019 Nov;
203(12):3126-3135.
PMID: 31748349
Ab-dependent cellular cytotoxicity (ADCC) is one of the most important effector mechanisms of tumor-targeting Abs in current immunotherapies. In ADCC and other Ab-dependent activation of myeloid effector cells, close cell-cell...
9.
Dilillo M, de Graaf E, Yadav A, Belov M, McDonnell L
J Proteome Res
. 2018 Nov;
18(1):557-564.
PMID: 30484663
The identification of molecular ions produced by MALDI or ESI strongly relies on their fragmentation to structurally informative fragments. The widely diffused fragmentation techniques for ESI multiply charged ions are...
10.
Dilillo M, Pellegrini D, Ait-Belkacem R, de Graaf E, Caleo M, McDonnell L
J Proteome Res
. 2017 Jun;
16(8):2993-3001.
PMID: 28648079
Mass spectrometry imaging (MSI) is able to simultaneously record the distributions of hundreds of molecules directly from tissue. Rapid direct tissue analysis is essential for MSI in order to maintain...