Erik B van den Akker
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Explore the profile of Erik B van den Akker including associated specialties, affiliations and a list of published articles.
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59
Citations
1542
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Recent Articles
1.
Sinke L, Beekman M, Raz Y, Gehrmann T, Moustakas I, Boulinguiez A, et al.
Aging Cell
. 2024 Dec;
:e14431.
PMID: 39618079
Across the lifespan, diet and physical activity profiles substantially influence immunometabolic health. DNA methylation, as a tissue-specific marker sensitive to behavioral change, may mediate these effects through modulation of transcription...
2.
Jia X, Fan J, Wu X, Cao X, Ma L, Abdelrahman Z, et al.
Adv Sci (Weinh)
. 2024 Sep;
11(43):e2406670.
PMID: 39331845
Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non-modifiable factors in metabolomic aging have not been...
3.
Bizzarri D, Reinders M, Kuiper L, Beekman M, Deelen J, van Meurs J, et al.
EBioMedicine
. 2024 Aug;
107:105279.
PMID: 39154540
Background: H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics data...
4.
van Holstein Y, Mooijaart S, van Oevelen M, van Deudekom F, Vojinovic D, Bizzarri D, et al.
Geroscience
. 2024 Jul;
46(6):5615-5627.
PMID: 38963649
Prognostic information is needed to balance benefits and risks of cancer treatment in older patients. Metabolomics-based scores were previously developed to predict 5- and 10-year mortality (MetaboHealth) and biological age...
5.
Karakaslar E, Severens J, Sanchez-Lopez E, Van Veelen P, Zlei M, van Dongen J, et al.
NPJ Precis Oncol
. 2024 May;
8(1):105.
PMID: 38762545
The diagnostic spectrum for AML patients is increasingly based on genetic abnormalities due to their prognostic and predictive value. However, information on the AML blast phenotype regarding their maturational arrest...
6.
Tulling A, Holierhoek M, Jansen-Hoogendijk A, Hoste L, Haerynck F, Tavernier S, et al.
Clin Immunol
. 2024 May;
264:110252.
PMID: 38744408
Children with Multisystem Inflammatory Syndrome in Children (MIS-C) can present with thrombocytopenia, which is a key feature of hemophagocytic lymphohistiocytosis (HLH). We hypothesized that thrombocytopenic MIS-C patients have more features...
7.
Karjalainen M, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung W, et al.
Nature
. 2024 Mar;
628(8006):130-138.
PMID: 38448586
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism. This detailed knowledge of the genetic determinants of systemic metabolism has been...
8.
Fuchs K, van de Meent M, Honders M, Khatri I, Kester M, Koster E, et al.
Blood
. 2024 Mar;
143(18):1856-1872.
PMID: 38427583
Allogeneic stem cell transplantation (alloSCT) is a curative treatment for hematological malignancies. After HLA-matched alloSCT, antitumor immunity is caused by donor T cells recognizing polymorphic peptides, designated minor histocompatibility antigens...
9.
Severens J, Karakaslar E, van der Reijden B, Sanchez-Lopez E, van den Berg R, Halkes C, et al.
Leukemia
. 2024 Feb;
38(4):751-761.
PMID: 38360865
Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense potential to further refine AML classification. Here we...
10.
Sterenborg R, Steinbrenner I, Li Y, Bujnis M, Naito T, Marouli E, et al.
Nat Commun
. 2024 Jan;
15(1):888.
PMID: 38291025
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals...