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Eric Van Otterloo

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Articles 26
Citations 625
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Recent Articles
1.
Petrin A, Machado-Paula L, Hinkle A, Hovey L, Awotoye W, Chimenti M, et al.
Cleft Palate Craniofac J . 2025 Jan; :10556656241306202. PMID: 39819101
Objective: Oculoauriculovertebral spectrum (OAVS) encompasses abnormalities on derivatives from the first and second pharyngeal arches including macrostomia, hemifacial microsomia, micrognathia, preauricular tags, ocular, and vertebral anomalies. We present genetic findings...
2.
Shao F, Phan A, Yu W, Guo Y, Thompson J, Coppinger C, et al.
PLoS Genet . 2024 Jul; 20(7):e1011364. PMID: 39052671
How the dorsal-ventral axis of the vertebrate jaw, particularly the position of tooth initiation site, is established remains a critical and unresolved question. Tooth development starts with the formation of...
3.
Alade A, Mossey P, Awotoye W, Busch T, Oladayo A, Aladenika E, et al.
Sci Rep . 2024 Jun; 14(1):14279. PMID: 38902479
Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability...
4.
Alade A, Peter T, Busch T, Awotoye W, Anand D, Abimbola O, et al.
Genet Epidemiol . 2024 Apr; 48(6):258-269. PMID: 38634654
Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%-80%) of all OFCs. They can be broadly categorized into nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft...
5.
Shao F, Van Otterloo E, Cao H
bioRxiv . 2024 Jan; PMID: 38187542
While many reptiles can replace their tooth throughout life, human loss the tooth replacement capability after formation of the permanent teeth. It was thought that the difference in tooth regeneration...
6.
Nguyen T, Mitchell J, Kiel M, Kenny C, Li H, Jones K, et al.
Development . 2023 Dec; 151(1). PMID: 38063857
Cranial neural crest development is governed by positional gene regulatory networks (GRNs). Fine-tuning of the GRN components underlies facial shape variation, yet how those networks in the midface are connected...
7.
Nguyen T, Mitchell J, Kiel M, Jones K, Williams T, Nichols J, et al.
bioRxiv . 2023 Jul; PMID: 37398373
Cranial neural crest development is governed by positional gene regulatory networks (GRNs). Fine-tuning of the GRN components underly facial shape variation, yet how those in the midface are connected and...
8.
Crawford J, Morawski M, Eliason S, Wuebker S, Van Otterloo E, Cao H, et al.
Orthod Craniofac Res . 2023 Apr; 26 Suppl 1:39-47. PMID: 37073503
Objective: The objective of the study was to investigate differential gene expression between murine right and left maxilla-mandibular (MxMn) complexes. Setting And Sample Population: Wild-type (WT) C57BL/6 embryonic (E) day...
9.
Kenny C, Dilshat R, Seberg H, Van Otterloo E, Bonde G, Helverson A, et al.
PLoS Genet . 2022 May; 18(5):e1010207. PMID: 35580127
In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of genes encoding pigmentation regulators, but their interaction...
10.
Van Otterloo E, Milanda I, Pike H, Thompson J, Li H, Jones K, et al.
Elife . 2022 Mar; 11. PMID: 35333176
The facial surface ectoderm is essential for normal development of the underlying cranial neural crest cell populations, providing signals that direct appropriate growth, patterning, and morphogenesis. Despite the importance of...