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Eric T Hedge

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Recent Articles
1.
Hedge E, Hughson R
J Appl Physiol (1985) . 2025 Feb; 138(3):816-824. PMID: 39992981
Recent investigations of middle cerebral artery blood velocity (MCAv) kinetics at the onset of exercise have not accounted for potential dynamic changes in arterial partial pressure of carbon dioxide ([Formula:...
2.
Hedge E, Mastrandrea C, Patterson C, Hughson R
J Appl Physiol (1985) . 2024 Dec; 138(1):226-237. PMID: 39656788
Reduced orthostatic tolerance is common following periods of bed rest that are associated with illness or surgery, putting individuals at higher risk for syncope and falls following hospitalization. Following menopause,...
3.
Hedge E, Brazile T, Hughson R, Levine B
J Physiol . 2024 Aug; PMID: 39162309
The human heart is very adaptable, with chamber size, wall thickness and ventricular stiffness all modified by periods of inactivity or exercise training. Herein, we summarize the cardiac adaptations induced...
4.
Cohen J, Hedge E, Greaves D, Robertson A, Nahas H, Yu A, et al.
J Appl Physiol (1985) . 2024 May; 137(1):32-41. PMID: 38813612
Blood volume shifts during postural adjustment lead to irregular distension of the internal jugular vein (IJV). In microgravity, distension may contribute to flow stasis and thromboembolism, though the regional implications...
5.
Mastrandrea C, Hedge E, Hughson R
Can J Cardiol . 2024 May; 40(8):1468-1482. PMID: 38759726
Bedrest as an experimental paradigm or as an in-patient stay for medical reasons has negative consequences for cardiovascular health. The effects of severe inactivity parallel many of the changes experienced...
6.
Murray K, Poirier J, Au J, Hedge E, Robertson A, Heckman G, et al.
CJC Open . 2024 Jan; 5(12):870-880. PMID: 38204855
Background: Insufficient cardiac output in individuals with heart failure (HF) limits daily functioning and reduces quality of life. Although lower cerebral perfusion, secondary to limitations in cardiac output, has been...
7.
Hedge E, Vico L, Hughson R, Mastrandrea C
JBMR Plus . 2023 Jul; 7(7):e10756. PMID: 37457881
Human skeletal hemodynamics remain understudied. Neither assessments in weight-bearing bones during walking nor following periods of immobility exist, despite knowledge of altered nutrient-artery characteristics after short-duration unloading in rodents. We...
8.
Hedge E, Amelard R, Hughson R
J Appl Physiol (1985) . 2023 May; 134(6):1530-1536. PMID: 37199779
Nonintrusive estimation of oxygen uptake (V̇o) is possible with wearable sensor technology and artificial intelligence. V̇o kinetics have been accurately predicted during moderate exercise using easy-to-obtain sensor inputs. However, V̇o...
9.
Mastrandrea C, Hedge E, Robertson A, Heckman G, Ho J, Granados Unger F, et al.
Am J Physiol Regul Integr Comp Physiol . 2023 May; 325(2):R107-R119. PMID: 37184226
Prolonged bedrest provokes orthostatic hypotension and intolerance of upright posture. Limited data are available on the cardiovascular responses of older adults to head-up tilt following bedrest, with no studies examining...
10.
Hedge E, Mastrandrea C, Hughson R
J Appl Physiol (1985) . 2023 Mar; 134(4):1022-1031. PMID: 36927144
Cardiorespiratory fitness declines with age and this decline can be accelerated by inactivity and bed rest. Recovery of fitness is possible, but the timeline in 55- to 65-yr-old adults is...