Eric Strengman
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Explore the profile of Eric Strengman including associated specialties, affiliations and a list of published articles.
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39
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3693
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Recent Articles
1.
van Belzen I, Cai C, van Tuil M, Badloe S, Strengman E, Janse A, et al.
BMC Cancer
. 2023 Jul;
23(1):618.
PMID: 37400763
Background: Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection. Recent...
2.
van Belzen I, van Tuil M, Badloe S, Strengman E, Janse A, Verwiel E, et al.
Cancers (Basel)
. 2022 Oct;
14(19).
PMID: 36230794
Chromosomal alterations have recurrently been identified in Wilms tumors (WTs) and some are associated with poor prognosis. Gain of 1q (1q+) is of special interest given its high prevalence and...
3.
Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, et al.
Nature
. 2022 Apr;
604(7906):502-508.
PMID: 35396580
Schizophrenia has a heritability of 60-80%, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and...
4.
Hehir-Kwa J, Koudijs M, Verwiel E, Kester L, van Tuil M, Strengman E, et al.
JCO Precis Oncol
. 2022 Jan;
6:e2000504.
PMID: 35085008
Purpose: Gene fusions play a significant role in cancer etiology, making their detection crucial for accurate diagnosis, prognosis, and determining therapeutic targets. Current diagnostic methods largely focus on either targeted...
5.
Strengman E, Barendrecht-Smouter F, de Voijs C, Vree P, Nijman I, de Leng W
Methods Mol Biol
. 2019 Jan;
1908:1-17.
PMID: 30649717
Next-generation sequencing (NGS) is rapidly becoming the method of choice for mutation analysis in both research and diagnostics. The benefit of targeted NGS compared to whole-genome and whole-exome sequencing is...
6.
Teo K, Gomez-Cuadrado L, Tenhagen M, Byron A, Ratze M, van Amersfoort M, et al.
Sci Rep
. 2018 Oct;
8(1):15454.
PMID: 30337563
Despite the fact that loss of E-cadherin is causal to the development and progression of invasive lobular carcinoma (ILC), options to treat this major breast cancer subtype are limited if...
7.
Broek R, Bekers E, de Leng W, Strengman E, Tops B, Kutzner H, et al.
Genes Chromosomes Cancer
. 2017 Aug;
56(12):855-860.
PMID: 28845532
Spindle cell hemangioma (SCH) is a distinct vascular soft-tissue lesion characterized by cavernous blood vessels and a spindle cell component mainly occurring in the distal extremities of young adults. The...
8.
Marshall C, Howrigan D, Merico D, Thiruvahindrapuram B, Wu W, Greer D, et al.
Nat Genet
. 2016 Nov;
49(1):27-35.
PMID: 27869829
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited...
9.
Kasteleijn-Nolst Trenite D, Volkers L, Strengman E, Schippers H, Perquin W, de Haan G, et al.
Seizure
. 2015 Jun;
29:90-6.
PMID: 26076849
Purpose: To determine clinical phenotypes, evolution and genetic background of a large family with a combination of two unusual forms of reflex epilepsies. Method: Phenotyping was performed in eighteen family...
10.
van Eijk K, de Jong S, Strengman E, Buizer-Voskamp J, Kahn R, Boks M, et al.
Eur J Hum Genet
. 2014 Nov;
23(8):1106-10.
PMID: 25424713
Emerging evidence suggests that schizophrenia (SZ) susceptibility involves variation at genetic, epigenetic and transcriptome levels. We describe an integrated approach that leverages DNA methylation and gene expression data to prioritize...