Eric Shields
Overview
Explore the profile of Eric Shields including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
46
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0
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Recent Articles
1.
Luo G, Chen L, Easton A, Newton A, Bourin C, Shields E, et al.
J Med Chem
. 2019 Feb;
62(4):2213.
PMID: 30734560
No abstract available.
2.
Luo G, Chen L, Easton A, Newton A, Bourin C, Shields E, et al.
J Med Chem
. 2018 Dec;
62(2):831-856.
PMID: 30576602
3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Na1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced complete Freund's adjuvant...
3.
Marcin L, Warrier J, Thangathirupathy S, Shi J, Karageorge G, Pearce B, et al.
ACS Med Chem Lett
. 2018 May;
9(5):472-477.
PMID: 29795762
There is a significant unmet medical need for more efficacious and rapidly acting antidepressants. Toward this end, negative allosteric modulators of the -methyl-d-aspartate receptor subtype GluN2B have demonstrated encouraging therapeutic...
4.
Bristow L, Gulia J, Weed M, Srikumar B, Li Y, Graef J, et al.
J Pharmacol Exp Ther
. 2017 Sep;
363(3):377-393.
PMID: 28954811
()-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3,4)-3-fluoro-1-((R)-1-(4-methylbenzyl)-2-oxopyrrolidin-3-yl)piperidin-4-yl)phenyl dihydrogen phosphate (BMS-986163) were identified from a drug discovery effort focused on the development of novel, intravenous glutamate -methyl-d-aspartate 2B receptor (GluN2B) negative...
5.
Narang A, Balakrishnan A, Morrison J, Li J, Wang J, Gu H, et al.
Eur J Pharm Biopharm
. 2017 Apr;
117:333-345.
PMID: 28455207
Variability in oral absorption in pre-clinical species makes human dose projection challenging. In this study, we investigated the mechanistic basis of variability in oral absorption of a model hydrophobic compound...
6.
Graef J, Newberry K, Newton A, Pieschl R, Shields E, Luan F, et al.
Brain Res
. 2015 Mar;
1609:31-9.
PMID: 25796435
The long lasting antidepressant response seen following acute, i.v. ketamine administration in patients with treatment-resistant depression (TRD) is thought to result from enhanced synaptic plasticity in cortical and hippocampal circuits....
7.
Benitex Y, Luan F, Shields E, Mcnaney C, Morgan D, Olah T, et al.
Bioanalysis
. 2014 Aug;
6(14):1901-5.
PMID: 25158962
Background: (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, also known as LY379268, a group II metabotropic glutamate receptor agonist, has been widely used in neuroscience as a model compound in studies evaluating antipsychotic drugs for...
8.
Altbuch T, Conrad B, Shields E, Farmer K
Cell Tissue Bank
. 2013 Mar;
14(4):673-7.
PMID: 23526125
The purpose of this study was to determine whether the pull-through force of soft-tissue allografts increases over time after being hydrated with saline-soaked sponges. Eighteen aseptic soft-tissue, fresh-frozen anterior tibialis...
9.
Shields E, Zhou W, Wang Y, Leger J
Appl Opt
. 2007 Nov;
46(31):7631-9.
PMID: 17973007
An imaging spectrometer with adaptive space-variant spectral resolution is introduced to improve spectrometer data collection efficiency. Pixel-based dynamically selectable dispersion is achieved using microelectromechanical system (MEMS) mirrors to control the...