Eric P Schultz
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Explore the profile of Eric P Schultz including associated specialties, affiliations and a list of published articles.
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11
Citations
85
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Recent Articles
1.
Zhao F, Atxabal U, Mariottini S, Yi F, Lotti J, Layeux M, et al.
J Med Chem
. 2025 Jan;
68(3):3572-3590.
PMID: 39847708
NMDA receptor ligands have therapeutic potential in neurological and psychiatric disorders. We designed ()-3-(5-thienyl)carboxamido-2-aminopropanoic acid derivatives with nanomolar agonist potencies at NMDA receptor subtypes (GluN12/A-D). These compounds are superagonists at...
2.
Schultz E, Ponsness L, Lanchy J, Zehner M, Klein F, Ryckman B
bioRxiv
. 2025 Jan;
PMID: 39829861
Herpesviruses require membrane fusion for entry and spread, a process facilitated by the fusion glycoprotein B (gB) and the regulatory factor gH/gL. The human cytomegalovirus (HCMV) gH/gL can be modified...
3.
Mielke J, Klingeborn M, Schultz E, Markham E, Reese E, Alam P, et al.
Acta Neuropathol
. 2024 Jun;
147(1):100.
PMID: 38884646
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2-5 years after diagnosis. The identification of novel prognostic and pharmacodynamic biomarkers are needed to facilitate...
4.
Zehner M, Alt M, Ashurov A, Goldsmith J, Spies R, Weiler N, et al.
Immunity
. 2023 Nov;
56(11):2602-2620.e10.
PMID: 37967532
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and immunocompromised individuals. Currently, no vaccines are approved, and treatment options are limited. Here, we analyzed the human B cell...
5.
Zhao F, Mazis G, Yi F, Lotti J, Layeux M, Schultz E, et al.
Front Chem
. 2022 Dec;
10:1008233.
PMID: 36465862
-Methyl-d-aspartate (NMDA) receptors play critical roles in central nervous system function and are involved in variety of brain disorders. We previously developed a series of ()-3-(5-furanyl)carboxamido-2-aminopropanoic acid glycine site agonists...
6.
Hayashi M, Schultz E, Lanchy J, Lodmell J
Viruses
. 2021 Dec;
13(12).
PMID: 34960686
Rift Valley fever virus (RVFV) is a negative-sense, tripartite RNA virus that is endemic to Africa and the Arabian Peninsula. It can cause severe disease and mortality in humans and...
7.
Schultz E, Yu Q, Stegmann C, Day L, Lanchy J, Ryckman B
J Virol
. 2021 Jun;
95(17):e0061221.
PMID: 34132577
Cell-free and cell-to-cell spread of herpesviruses involves a core fusion apparatus comprised of the fusion protein glycoprotein B (gB) and the regulatory factor gH/gL. The human cytomegalovirus (HCMV) gH/gL/gO and...
8.
Siddiquey M, Schultz E, Yu Q, Amendola D, Vezzani G, Yu D, et al.
J Virol
. 2021 May;
95(15):e0220720.
PMID: 34011552
Heterodimers of glycoproteins H (gH) and L (gL) comprise a basal element of the viral membrane fusion machinery conserved across herpesviruses. In human cytomegalovirus (HCMV), the glycoprotein UL116 assembles onto...
9.
Schultz E, Lanchy J, Day L, Yu Q, Peterson C, Preece J, et al.
J Virol
. 2020 Apr;
94(13).
PMID: 32321807
It is widely held that clinical isolates of human cytomegalovirus (HCMV) are highly cell associated, and mutations affecting the UL128-131 and RL13 loci that arise in culture lead to the...
10.
Day L, Stegmann C, Schultz E, Lanchy J, Yu Q, Ryckman B
J Virol
. 2020 Jan;
94(8).
PMID: 31996433
Human cytomegalovirus (HCMV) glycoproteins H and L (gH/gL) can be bound by either gO or the UL128 to UL131 proteins (referred to here as UL128-131) to form complexes that facilitate...