Eric J Jaehnig
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Explore the profile of Eric J Jaehnig including associated specialties, affiliations and a list of published articles.
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2750
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Recent Articles
1.
Savage S, Yi X, Lei J, Wen B, Zhao H, Liao Y, et al.
Cell
. 2024 Jun;
187(16):4389-4407.e15.
PMID: 38917788
Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug Administration (FDA). We integrate Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomics data from 1,043 patients...
2.
Jiang W, Jaehnig E, Liao Y, Yaron-Barir T, Johnson J, Cantley L, et al.
bioRxiv
. 2024 Apr;
PMID: 38562798
Mass spectrometry-based phosphoproteomics offers a comprehensive view of protein phosphorylation, but limited knowledge about the regulation and function of most phosphosites restricts our ability to extract meaningful biological insights from...
3.
Saltzman A, Chan D, Holt M, Wang J, Jaehnig E, Anurag M, et al.
Clin Proteomics
. 2024 Jan;
21(1):3.
PMID: 38225548
Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quantification of the protein...
4.
Yi X, Wen B, Ji S, Saltzman A, Jaehnig E, Lei J, et al.
Mol Cell Proteomics
. 2023 Dec;
23(2):100707.
PMID: 38154692
Shotgun phosphoproteomics enables high-throughput analysis of phosphopeptides in biological samples. One of the primary challenges associated with this technology is the relatively low rate of phosphopeptide identification during data analysis....
5.
Savage S, Zhang Y, Jaehnig E, Liao Y, Shi Z, Pham H, et al.
Mol Cell Proteomics
. 2023 Nov;
23(1):100682.
PMID: 37993103
Global phosphoproteomics experiments quantify tens of thousands of phosphorylation sites. However, data interpretation is hampered by our limited knowledge on functions, biological contexts, or precipitating enzymes of the phosphosites. This...
6.
Wang J, Saltzman A, Jaehnig E, Lei J, Malovannaya A, Holt M, et al.
Cancer Res Commun
. 2023 Aug;
3(8):1551-1563.
PMID: 37587913
Significance: The identification of pretreatment predictive biomarkers for pCR in response to neoadjuvant chemotherapy would advance precision treatment for TNBC. To complement standard proteogenomic discovery profiling, a KIPA was deployed...
7.
Li Y, Dou Y, Veiga Leprevost F, Geffen Y, Calinawan A, Aguet F, et al.
Cancer Cell
. 2023 Aug;
41(8):1397-1406.
PMID: 37582339
The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets connecting genomic aberrations to cancer phenotypes. To facilitate pan-cancer investigations,...
8.
Lei J, Jaehnig E, Smith H, Holt M, Li X, Anurag M, et al.
Cold Spring Harb Perspect Med
. 2023 May;
13(10).
PMID: 37137501
The goal of precision oncology is to translate the molecular features of cancer into predictive and prognostic tests that can be used to individualize treatment leading to improved outcomes and...
9.
Yi X, Wen B, Ji S, Saltzman A, Jaehnig E, Lei J, et al.
bioRxiv
. 2023 Jan;
PMID: 36711982
Shotgun phosphoproteomics enables high-throughput analysis of phosphopeptides in biological samples, but low phosphopeptide identification rate in data analysis limits the potential of this technology. Here we present DeepRescore2, a computational...
10.
Wen B, Jaehnig E, Zhang B
Bioinformatics
. 2022 Oct;
38(24):5463-5465.
PMID: 36271853
Summary: RNA-Seq and mass spectrometry-based studies generate omics data tables with measurements for tens of thousands of genes across all samples in a study. The success of a study relies...