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Eric F C Cheung

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Articles 206
Citations 2993
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Recent Articles
1.
Zhong Y, Tubbs J, Leung P, Zhan N, Hui T, Ho K, et al.
Asian J Psychiatr . 2024 Apr; 96:104046. PMID: 38663229
Rare and low-frequency variants contribute to schizophrenia (SCZ), and may influence its age-at-onset (AAO). We examined the association of rare or low-frequency deleterious coding variants in Chinese patients with SCZ....
2.
Zhong Y, Tubbs J, Leung P, Zhan N, Hui T, Ho K, et al.
medRxiv . 2023 Dec; PMID: 38045317
Background: Rare variants are likely to contribute to schizophrenia (SCZ), given the large discrepancy between the heritability estimated from twin and GWAS studies. Furthermore, the nature of the rare-variant contribution...
3.
Tubbs J, Leung P, Zhong Y, Zhan N, Hui T, Ho K, et al.
medRxiv . 2023 Oct; PMID: 37790317
Psychotic disorders are debilitating conditions with disproportionately high public health burden. Genetic studies indicate high heritability, but current polygenic scores (PGS) account for only a fraction of variance in psychosis...
4.
Lui S, Wang L, Lau W, Shing E, Yeung H, Tsang K, et al.
Asian J Psychiatr . 2023 Jan; 81:103467. PMID: 36669292
Background: Emotion-behaviour decoupling refers to the failure to translate emotion into motivated behaviour, and is a putative marker for schizophrenia. The heterogeneity of experiential pleasure and emotion expressivity deficits has...
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Li S, Liu C, Zhang J, Wang L, Hu H, Chu M, et al.
Schizophr Res . 2022 Aug; 248:131-139. PMID: 36037646
Background: Negative symptoms are core symptom of schizophrenia, and many previous research studied the latent structure of negative symptoms based on a single measurement scale. Applying two second-generation negative symptom...
7.
Cai X, Pu C, Zhou S, Wang Y, Huang J, Lui S, et al.
Psychol Med . 2022 Jul; 53(11):4904-4914. PMID: 35791929
Background: Glutamatergic dysfunction has been implicated in sensory integration deficits in schizophrenia, yet how glutamatergic function contributes to behavioural impairments and neural activities of sensory integration remains unknown. Methods: Fifty...
8.
Hu H, Lau W, Ma E, Hung K, Chen S, Cheng K, et al.
Schizophr Bull . 2022 May; 48(4):860-870. PMID: 35524755
Negative symptoms, particularly the motivation and pleasure (MAP) deficits, are associated with impaired social functioning in patients with schizophrenia (SCZ). However, previous studies seldom examined the role of the MAP...
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Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, et al.
Nature . 2022 Apr; 604(7906):502-508. PMID: 35396580
Schizophrenia has a heritability of 60-80%, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and...
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Lui S, Zhang R, Lau W, Liu A, Chui W, Wang Y, et al.
J Clin Psychiatry . 2022 Feb; 83(2). PMID: 35143123
Prospective memory (PM) impairment is associated with impaired social functioning, but evidence is limited to chronic schizophrenia samples and cross-sectional design. The aim of this study was to utilize network...