Ergun Sahin
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Explore the profile of Ergun Sahin including associated specialties, affiliations and a list of published articles.
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29
Citations
3754
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Recent Articles
1.
Maneix L, Iakova P, Lee C, Moree S, Lu X, Datar G, et al.
Nat Cell Biol
. 2024 Mar;
26(4):593-603.
PMID: 38553595
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as a dominant chaperone in haematopoietic stem and progenitor cells....
2.
Maneix L, Iakova P, Moree S, Hsu J, Mistry R, Stossi F, et al.
Cancer Res Commun
. 2023 Feb;
2(12):1693-1710.
PMID: 36846090
Proteasome inhibitors have become the standard of care for multiple myeloma (MM). Blocking protein degradation particularly perturbs the homeostasis of short-lived polypeptides such as transcription factors and epigenetic regulators. To...
3.
Moree S, Maneix L, Iakova P, Stossi F, Sahin E, Catic A
Cancers (Basel)
. 2022 Feb;
14(3).
PMID: 35159073
The ubiquitin-proteasome pathway precisely controls the turnover of transcription factors in the nucleus, playing an important role in maintaining appropriate quantities of these regulatory proteins. The transcription factor c-MYC is...
4.
Thongon N, Ma F, Santoni A, Marchesini M, Fiorini E, Rose A, et al.
Nat Commun
. 2021 Nov;
12(1):6850.
PMID: 34824242
The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to...
5.
Freise C, Lee H, Chronowski C, Chan D, Cziomer J, Ruhl M, et al.
PLoS One
. 2021 Sep;
16(9):e0254557.
PMID: 34473704
The interaction of extracellular matrix (ECM) components with hepatic stellate cells (HSCs) is thought to perpetuate fibrosis by stimulating signaling pathways that drive HSC activation, survival and proliferation. Consequently, disrupting...
6.
Chronowski C, Akhanov V, Chan D, Catic A, Finegold M, Sahin E
Metabolites
. 2021 Jul;
11(6).
PMID: 34204343
Studies in humans and model systems have established an important role of short telomeres in predisposing to liver fibrosis through pathways that are incompletely understood. Recent studies have shown that...
7.
Maneix L, Sweeney M, Lee S, Iakova P, Moree S, Sahin E, et al.
Cancers (Basel)
. 2021 Mar;
13(4).
PMID: 33671345
Multiple myeloma and its precursor plasma cell dyscrasias affect 3% of the elderly population in the US. Proteasome inhibitors are an essential part of several standard drug combinations used to...
8.
Sweeney M, Iakova P, Maneix L, Shih F, Cho H, Sahin E, et al.
Sci Rep
. 2020 Aug;
10(1):13942.
PMID: 32811853
Transcription is regulated through a dynamic interplay of DNA-associated proteins, and the composition of gene-regulatory complexes is subject to continuous adjustments. Protein alterations include post-translational modifications and elimination of individual...
9.
Amano H, Sahin E
Mol Cell Oncol
. 2019 Sep;
6(5):e1632613.
PMID: 31528700
Telomeres and sirtuins are independently implicated in causing disease and aging, but how they cooperate is not well understood. A recent study demonstrates that telomere shortening represses sirtuins and increasing...
10.
Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, et al.
Cell Metab
. 2019 Apr;
29(6):1274-1290.e9.
PMID: 30930169
Telomere shortening is associated with stem cell decline, fibrotic disorders, and premature aging through mechanisms that are incompletely understood. Here, we show that telomere shortening in livers of telomerase knockout...