Enzo Tedone
Overview
Explore the profile of Enzo Tedone including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
439
Followers
0
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Recent Articles
1.
Rosso I, Jones-Weinert C, Rossiello F, Cabrini M, Brambillasca S, Munoz-Sagredo L, et al.
Nat Commun
. 2023 Nov;
14(1):7086.
PMID: 37925537
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10-15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional telomeres...
2.
Mender I, Siteni S, Barron S, Flusche A, Kubota N, Yu C, et al.
Mol Cancer Ther
. 2023 Apr;
22(6):737-750.
PMID: 37070671
A select group of patients with hepatocellular carcinomas (HCC) benefit from surgical, radiologic, and systemic therapies that include a combination of anti-angiogenic and immune-checkpoint inhibitors. However, because HCC is generally...
3.
Vessoni A, Zhang T, Quinet A, Jeong H, Munroe M, Wood M, et al.
J Cell Biol
. 2021 Apr;
220(6).
PMID: 33851958
It is well established that short telomeres activate an ATM-driven DNA damage response that leads to senescence in terminally differentiated cells. However, technical limitations have hampered our understanding of how...
4.
Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly"
Arosio B, DAddario C, Gussago C, Casati M, Tedone E, Ferri E, et al.
Biomed Res Int
. 2020 Oct;
2020:9175369.
PMID: 33005690
[This corrects the article DOI: 10.1155/2014/169203.].
5.
Peters-Hall J, Min J, Tedone E, Sho S, Siteni S, Mender I, et al.
FASEB J
. 2020 Jan;
34(1):386-398.
PMID: 31914653
To date, there is no direct evidence of telomerase activity in adult lung epithelial cells, but typical culture conditions only support cell proliferation for 30-40 population doublings (PD), a point...
6.
OHara R, Tedone E, Ludlow A, Huang E, Arosio B, Mari D, et al.
Genome Res
. 2019 Sep;
29(11):1878-1888.
PMID: 31548359
Mitochondria are involved in a number of diverse cellular functions, including energy production, metabolic regulation, apoptosis, calcium homeostasis, cell proliferation, and motility, as well as free radical generation. Mitochondrial DNA...
7.
Li Y, Zhou G, Bruno I, Zhang N, Sho S, Tedone E, et al.
Aging Cell
. 2019 Jun;
18(4):e12979.
PMID: 31152494
Hutchinson-Gilford progeria syndrome (HGPS) is characterized by accelerated senescence due to a de novo mutation in the LMNA gene. The mutation produces an abnormal lamin A protein called progerin that...
8.
Sayed M, Yuan L, Robin J, Tedone E, Batten K, Dahlson N, et al.
Oncogene
. 2018 Dec;
38(16):2937-2952.
PMID: 30568224
Alternative splicing is dysregulated in cancer cells, driving the production of isoforms that allow tumor cells to survive and continuously proliferate. Part of the reactivation of telomerase involves the splicing...
9.
Tedone E, Huang E, OHara R, Batten K, Ludlow A, Lai T, et al.
Aging Cell
. 2018 Nov;
18(1):e12859.
PMID: 30488553
It is generally recognized that the function of the immune system declines with increased age and one of the major immune changes is impaired T-cell responses upon antigen presentation/stimulation. Some...
10.
Ludlow A, Wong M, Robin J, Batten K, Yuan L, Lai T, et al.
Nat Commun
. 2018 Aug;
9(1):3112.
PMID: 30082712
Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the splicing of TERT transcripts to produce full-length (FL) TERT. Knowledge about the splicing factors that enhance or...