Engy Shokry
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Explore the profile of Engy Shokry including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
203
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Recent Articles
1.
Jans M, Kolata M, Blancke G, DHondt A, Graf C, Ciers M, et al.
Nature
. 2024 Nov;
635(8038):472-480.
PMID: 39506107
Various bacteria are suggested to contribute to colorectal cancer (CRC) development, including pks Escherichia coli, which produces the genotoxin colibactin that induces characteristic mutational signatures in host epithelial cells. However,...
2.
Ackermann T, Shokry E, Deshmukh R, Anand J, Galbraith L, Mitchell L, et al.
EMBO Mol Med
. 2024 Oct;
16(11):2749-2774.
PMID: 39433871
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell...
3.
Zarou M, Rattigan K, Sarnello D, Shokry E, Dawson A, Ianniciello A, et al.
Nat Commun
. 2024 Mar;
15(1):1931.
PMID: 38431691
Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully...
4.
Eberhart T, Stanley F, Ricci L, Chirico T, Ferrarese R, Sisti S, et al.
Cell Death Dis
. 2024 Feb;
15(2):105.
PMID: 38302438
Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating inflammation and microbe survival. However, at...
5.
Mahmood M, Liu E, Shergold A, Tolla E, Tait-Mulder J, Huerta-Uribe A, et al.
Nat Cancer
. 2024 Jan;
5(4):659-672.
PMID: 38286828
The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated regions of the cancer genome, but whether these mutations...
6.
Barbosa J, Shokry E, David L, Pereira N, da Silva A, de Oliveira V, et al.
Mol Omics
. 2023 Sep;
20(1):27-36.
PMID: 37751172
Cancer is one of the deadliest diseases in humans and dogs. Nevertheless, most tumor types spread faster in canines, and early cancer detection methods are necessary to enhance animal survival....
7.
Vande Voorde J, Steven R, Najumudeen A, Ford C, Dexter A, Gonzalez-Fernandez A, et al.
Nat Metab
. 2023 Aug;
5(8):1303-1318.
PMID: 37580540
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered...
8.
Rattigan K, Zarou M, Brabcova Z, Prasad B, Zerbst D, Sarnello D, et al.
EMBO Rep
. 2023 Jul;
24(10):e56279.
PMID: 37489735
To fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which can result in specific nutrient dependencies. Here, we perform an amino acid drop-out screen and apply pre-clinical models of chronic...
9.
Mahmood M, Liu E, Shergold A, Tolla E, Tait-Mulder J, Uribe A, et al.
bioRxiv
. 2023 Mar;
PMID: 36993533
The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in...
10.
Marques J, Shokry E, Uhl O, Baber L, Hofmeister F, Jarmusch S, et al.
Skelet Muscle
. 2023 Jan;
13(1):2.
PMID: 36658632
Background: Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and generalized loss of muscle mass with a simultaneous reduction in muscle strength...