Emma S Garratt
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Explore the profile of Emma S Garratt including associated specialties, affiliations and a list of published articles.
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11
Citations
264
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Recent Articles
1.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee A, et al.
Nat Metab
. 2024 Mar;
6(3):433-447.
PMID: 38504132
Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD) levels are hallmarks of skeletal muscle ageing and sarcopenia, but it is unclear whether these defects result from local changes or can...
2.
Burton M, Antoun E, Garratt E, Westbury L, Dennison E, Harvey N, et al.
FASEB J
. 2024 Jan;
38(3):e23423.
PMID: 38294260
Small noncoding RNAs (sncRNAs) are implicated in age-associated pathologies, including sarcopenia and insulin resistance (IR). As potential circulating biomarkers, most studies have focussed on microRNAs (miRNAs), one class of sncRNA....
3.
Burton M, Garratt E, Hewitt M, Sharkh H, Antoun E, Westbury L, et al.
Skelet Muscle
. 2023 Oct;
13(1):17.
PMID: 37898813
Background: While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated...
4.
Burton M, Antoun E, Garratt E, Westbury L, Baczynska A, Dennison E, et al.
J Cachexia Sarcopenia Muscle
. 2023 May;
14(4):1762-1774.
PMID: 37199333
Background: Amongst healthy older people, a number of correlates of impaired skeletal muscle mass and function have been defined. Although the prevalence of obesity is increasing markedly in this age...
5.
Antoun E, Garratt E, Taddei A, Burton M, Barton S, Titcombe P, et al.
J Cachexia Sarcopenia Muscle
. 2021 Dec;
13(1):240-253.
PMID: 34862756
Background: Sarcopenia is the age-related loss of muscle mass, strength, and function. Epigenetic processes such as DNA methylation, which integrate both genetic and environmental exposures, have been suggested to contribute...
6.
Antoun E, Kitaba N, Titcombe P, Dalrymple K, Garratt E, Barton S, et al.
PLoS Med
. 2020 Nov;
17(11):e1003229.
PMID: 33151971
Background: Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we...
7.
Migliavacca E, Tay S, Patel H, Sonntag T, Civiletto G, McFarlane C, et al.
Nat Commun
. 2019 Dec;
10(1):5808.
PMID: 31862890
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly...
8.
Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood
Lillycrop K, Garratt E, Titcombe P, Melton P, Murray R, Barton S, et al.
Int J Obes (Lond)
. 2019 Jan;
43(5):974-988.
PMID: 30622309
Background: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a...
9.
Lillycrop K, Costello P, Teh A, Murray R, Clarke-Harris R, Barton S, et al.
Int J Epidemiol
. 2015 Apr;
44(4):1263-76.
PMID: 25906782
Background: Early life environments induce long-term changes in neurocognitive development and behaviour. In animal models, early environmental cues affect neuropsychological phenotypes via epigenetic processes but, as yet, there is little...
10.
Garratt E, Vickers M, Gluckman P, Hanson M, Burdge G, Lillycrop K
PLoS One
. 2013 Jul;
8(6):e67483.
PMID: 23825665
The genes encoding nuclear receptors comprise multiple 5'untranslated exons, which give rise to several transcripts encoding the same protein, allowing tissue-specific regulation of expression. Both human and mouse peroxisome proliferator...