Emilie Caron
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Explore the profile of Emilie Caron including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Barelle P, Sicardi A, Schaller F, Buron J, Becquet D, Omnes F, et al.
JCI Insight
. 2025 Mar;
PMID: 40048253
Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of seven contiguous paternally expressed genes. Mouse models with inactivation of all PWS genes are lethal. Knockout (KO) mouse...
2.
Duquenne M, Deligia E, Folgueira C, Bourouh C, Caron E, Pfrieger F, et al.
Mol Metab
. 2024 Jul;
87:101996.
PMID: 39047908
Objectives: In Western society, high-caloric diets rich in fats and sugars have fueled the obesity epidemic and its related disorders. Disruption of the body-brain communication, crucial for maintaining glucose and...
3.
Bourouh C, Courty E, Rolland L, Pasquetti G, Gromada X, Rabhi N, et al.
Cell Rep
. 2022 Aug;
40(6):111170.
PMID: 35947949
The glucagon-like peptide 1 (Glp-1) has emerged as a hormone with broad pharmacological potential in type 2 diabetes (T2D) treatment, notably by improving β cell functions. The cell-cycle regulator and...
4.
Benderradji H, Kraiem S, Courty E, Eddarkaoui S, Bourouh C, Faivre E, et al.
Front Mol Neurosci
. 2022 Mar;
15:841892.
PMID: 35250480
Alzheimer's disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been...
5.
Collden G, Caron E, Bouret S
Int J Obes (Lond)
. 2022 Feb;
46(6):1138-1144.
PMID: 35173277
Background/objectives: Alteration of the perinatal nutritional environment is an important risk factor for the development of metabolic diseases in later life. The hormone leptin plays a critical role in growth...
6.
Deckmyn B, Domenger D, Blondel C, Ducastel S, Nicolas E, Dorchies E, et al.
Front Mol Neurosci
. 2022 Jan;
14:808603.
PMID: 35058750
The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis in peripheral organs. Indeed, enterohepatic-expressed FXR controls metabolic processes (BA, glucose and lipid...
7.
Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function
Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, et al.
Nat Metab
. 2021 Aug;
3(8):1071-1090.
PMID: 34341568
Metabolic health depends on the brain's ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain...
8.
Rohrbach A, Caron E, Dali R, Brunner M, Pasquettaz R, Kolotuev I, et al.
Mol Metab
. 2021 Jul;
53:101311.
PMID: 34325016
Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated...
9.
Lhomme T, Clasadonte J, Imbernon M, Fernandois D, Sauve F, Caron E, et al.
J Clin Invest
. 2021 Jul;
131(18).
PMID: 34324439
Hypothalamic glucose sensing enables an organism to match energy expenditure and food intake to circulating levels of glucose, the main energy source of the brain. Here, we established that tanycytes...
10.
Leboucher A, Ahmed T, Caron E, Tailleux A, Raison S, Joly-Amado A, et al.
Neurobiol Dis
. 2019 Jan;
125:14-22.
PMID: 30665005
Accumulation of hyper-phosphorylated and aggregated Tau proteins is a neuropathological hallmark of Alzheimer's Disease (AD) and Tauopathies. AD patient brains also exhibit insulin resistance. Whereas, under normal physiological conditions insulin...