Emile J A X van de Sandt
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Explore the profile of Emile J A X van de Sandt including associated specialties, affiliations and a list of published articles.
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9
Citations
35
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Recent Articles
1.
Pirrung S, van der Wielen L, Van Beckhoven R, van de Sandt E, Eppink M, Ottens M
Biotechnol Prog
. 2017 Jan;
33(3):696-707.
PMID: 28054462
Downstream process development is a major area of importance within the field of bioengineering. During the design of such a downstream process, important decisions have to be made regarding the...
2.
Hanke A, Tsintavi E, Ramirez Vazquez M, van der Wielen L, Verhaert P, Eppink M, et al.
Biotechnol Prog
. 2016 Jun;
32(5):1283-1291.
PMID: 27302666
Knowledge-based development of chromatographic separation processes requires efficient techniques to determine the physicochemical properties of the product and the impurities to be removed. These characterization techniques are usually divided into...
3.
Hanke A, Klijn M, Verhaert P, van der Wielen L, Ottens M, Eppink M, et al.
Biotechnol Prog
. 2015 Dec;
32(2):372-81.
PMID: 26698169
The correlation between the dimensionless retention times (DRT) of proteins in hydrophobic interaction chromatography (HIC) and their surface properties were investigated. A ternary atomic-level hydrophobicity scale was used to calculate...
4.
Hanke A, Verhaert P, van der Wielen L, Eppink M, van de Sandt E, Ottens M
J Chromatogr A
. 2015 Apr;
1394:54-61.
PMID: 25841612
Lower order peak moments of individual peaks in heavily fused peak clusters can be determined by fitting peak models to the experimental data. The success of such an approach depends...
5.
Lin D, Shi W, Tong H, van de Sandt E, den Boer P, Ferreira G, et al.
J Chromatogr A
. 2015 Mar;
1393:65-72.
PMID: 25817706
Expanded bed adsorption (EBA) is a promising technology to capture proteins directly from unclarified feedstock. In order to better understand liquid mixing along the bed height in expanded beds, an...
6.
Lin D, Tong H, van de Sandt E, den Boer P, Golubovic M, Yao S
J Chromatogr A
. 2013 Jul;
1304:78-84.
PMID: 23871286
Expanded bed adsorption (EBA) is an innovative chromatography technology that allows the adsorption of target proteins directly from unclarified feedstock, and the most important property of an expanded bed is...
7.
Nfor B, Ahamed T, Pinkse M, van der Wielen L, Verhaert P, van Dedem G, et al.
Biotechnol Bioeng
. 2012 Jun;
109(12):3070-83.
PMID: 22688729
A multi-dimensional fractionation and characterization scheme was developed for fast acquisition of the relevant molecular properties for protein separation from crude biological feedstocks by ion-exchange chromatography (IEX), hydrophobic interaction chromatography...
8.
Ahamed T, Chilamkurthi S, Nfor B, Verhaert P, van Dedem G, van der Wielen L, et al.
J Chromatogr A
. 2007 Dec;
1194(1):22-9.
PMID: 18154981
This work demonstrates that the type of ion-exchanger (anion or cation), the mode of operation (bind-and-elute or flow-through), and the operational pH of ion-exchange chromatography (IEX) can be selected in...
9.
Ahamed T, Nfor B, Verhaert P, van Dedem G, van der Wielen L, Eppink M, et al.
J Chromatogr A
. 2007 Aug;
1164(1-2):181-8.
PMID: 17673242
This work demonstrates that a highly linear, controllable and wide-ranged pH-gradient can be generated through an ion-exchange chromatography (IEC) column. Such a pH-gradient anion-exchange chromatography was evaluated with 17 model...