Emil Spreitzer
Overview
Explore the profile of Emil Spreitzer including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
378
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Recent Articles
1.
Jean-Quartier C, Stryeck S, Thien A, Vrella B, Kleinschuster J, Spreitzer E, et al.
Digit Health
. 2024 Sep;
10:20552076241271769.
PMID: 39281045
Objective: Data sharing promotes the scientific progress. However, not all data can be shared freely due to privacy issues. This work is intended to foster FAIR sharing of sensitive data...
2.
Usluer S, Galhuber M, Khanna Y, Bourgeois B, Spreitzer E, Michenthaler H, et al.
Biochim Biophys Acta Mol Cell Res
. 2023 Dec;
1871(2):119654.
PMID: 38123020
The genome is frequently targeted by genotoxic agents, resulting in the formation of DNA scars. However, cells employ diverse repair mechanisms to restore DNA integrity. Among these processes, the Mre11-Rad50-Nbs1...
3.
Galhuber M, Michenthaler H, Heininger C, Reinisch I, Nossing C, Krstic J, et al.
Cell Mol Life Sci
. 2022 May;
79(6):326.
PMID: 35635656
Signaling trough p53is a major cellular stress response mechanism and increases upon nutrient stresses such as starvation. Here, we show in a human hepatoma cell line that starvation leads to...
4.
Spreitzer E, Alderson T, Bourgeois B, Eggenreich L, Habacher H, Brahmersdorfer G, et al.
Curr Res Struct Biol
. 2022 May;
4:118-133.
PMID: 35573459
Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein...
5.
Zhang F, Richter G, Bourgeois B, Spreitzer E, Moser A, Keilbach A, et al.
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35056965
A fundamental step in developing a protein drug is the selection of a stable storage formulation that ensures efficacy of the drug and inhibits physiochemical degradation or aggregation. Here, we...
6.
Usluer S, Spreitzer E, Bourgeois B, Madl T
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768862
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR dipeptide repeats, which are encoded by the chromosome 9 open reading...
7.
Bourgeois B, Gui T, Hoogeboom D, Hocking H, Richter G, Spreitzer E, et al.
Cell Rep
. 2021 Jul;
36(4):109446.
PMID: 34320339
Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity. Here, we present a detailed...
8.
Spreitzer E, Usluer S, Madl T
J Mol Biol
. 2020 Mar;
432(9):2949-2972.
PMID: 32135192
Proteins and their interactions control a plethora of biological functions and enable life. Protein-protein interactions can be highly dynamic, involve proteins with different degrees of "foldedness," and are often regulated...
9.
Hartlmuller C, Spreitzer E, Gobl C, Falsone F, Madl T
J Biomol NMR
. 2019 Jul;
73(6-7):305-317.
PMID: 31297688
In order to understand the conformational behavior of intrinsically disordered proteins (IDPs) and their biological interaction networks, the detection of residual structure and long-range interactions is required. However, the large...
10.
Merle D, Witternigg A, Tam-Amersdorfer C, Hartlmuller C, Spreitzer E, Schrank E, et al.
J Mol Biol
. 2019 Apr;
431(14):2581-2598.
PMID: 31034892
The recent discovery of biologically active fully disordered, so called random fuzzy protein-protein interactions leads to the question of how the high flexibility of these protein complexes correlates to aggregation...