Emi Aizawa
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Explore the profile of Emi Aizawa including associated specialties, affiliations and a list of published articles.
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26
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1813
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Recent Articles
1.
Li M, Suzuki K, Wang M, Benner C, Ku M, Ma L, et al.
Sci China Life Sci
. 2025 Mar;
PMID: 40080269
Human pluripotent stem cells (hPSCs) can in theory give rise to any hematopoietic lineages, thereby offering opportunities for disease modeling, drug screening and cell therapies. However, gaps in our knowledge...
2.
Yamada M, Aizawa E, Dohi A, Sasaguri K, Yamamoto T, Noguchi T
Cells Tissues Organs
. 2025 Feb;
:1-19.
PMID: 39999804
Introduction: Hemolymph nodes, characterized by erythrocyte rosettes, are found in humans and animals, including rats. The cytoarchitectural differences they share with lymph nodes and the spleen are unknown. Herein, we...
3.
Hirose J, Aizawa E, Yamamoto S, Xu M, Iwai S, Suzuki K
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766265
In vivo genome editing holds great therapeutic potential for treating monogenic diseases by enabling precise gene correction or addition. However, improving the efficiency of delivery systems remains a key challenge....
4.
Shen Q, Suga S, Moriwaki Y, Du Z, Aizawa E, Okazaki M, et al.
J Dermatol Sci
. 2024 Aug;
115(3):101-110.
PMID: 39127592
Background: Local gene therapies, including in vivo genome editing, are highly anticipated for the treatment of genetic diseases in skin, especially the epidermis. While the adeno-associated virus (AAV) is a...
5.
Liu M, Zhang C, Gong X, Zhang T, Lian M, Chew E, et al.
Cell Stem Cell
. 2024 Jan;
31(1):52-70.e8.
PMID: 38181751
Human pluripotent stem cell-derived kidney organoids offer unprecedented opportunities for studying polycystic kidney disease (PKD), which still has no effective cure. Here, we developed both in vitro and in vivo...
6.
Karasawa T, Komada T, Baatarjav C, Aizawa E, Mizushina Y, Fujimura K, et al.
Biochem Biophys Res Commun
. 2023 Nov;
686:149158.
PMID: 37922574
Caspase-11 is an inflammatory caspase that triggers an inflammatory response by regulating non-canonical NLRP3 inflammasome activation. Although the deficiency of both caspase-11 and caspase-1, another inflammatory caspase that functions as...
7.
Yuan B, Zhou X, Suzuki K, Ramos-Mandujano G, Wang M, Tehseen M, et al.
Nat Commun
. 2022 Sep;
13(1):5291.
PMID: 36075901
No abstract available.
8.
Yuan B, Zhou X, Suzuki K, Ramos-Mandujano G, Wang M, Tehseen M, et al.
Nat Commun
. 2022 Jun;
13(1):3646.
PMID: 35752626
The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome...
9.
Kuwayama R, Suzuki K, Nakamura J, Aizawa E, Yoshioka Y, Ikawa M, et al.
Nat Commun
. 2022 Jun;
13(1):3107.
PMID: 35661110
Inherited glycosylphosphatidylinositol (GPI) deficiency (IGD) is caused by mutations in GPI biosynthesis genes. The mechanisms of its systemic, especially neurological, symptoms are not clarified and fundamental therapy has not been...
10.
Karasawa T, Komada T, Yamada N, Aizawa E, Mizushina Y, Watanabe S, et al.
Elife
. 2022 May;
11.
PMID: 35616535
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation...