Emerald Perlas
Overview
Explore the profile of Emerald Perlas including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1216
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Recent Articles
1.
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Grosch M, Schraft L, Chan A, Kuchenhoff L, Rapti K, Ferreira A, et al.
Nat Commun
. 2023 Jun;
14(1):3714.
PMID: 37349314
Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to...
2.
Neniskyte U, Kuliesiute U, Vadisiute A, Jevdokimenko K, Coletta L, Deivasigamani S, et al.
EMBO J
. 2023 May;
42(14):e111790.
PMID: 37211968
The mature mammalian brain connectome emerges during development via the extension and pruning of neuronal connections. Glial cells have been identified as key players in the phagocytic elimination of neuronal...
3.
Vito F, Balletta S, Caioli S, Musella A, Guadalupi L, Vanni V, et al.
Curr Neuropharmacol
. 2023 Apr;
21(12):2567-2582.
PMID: 37021418
Background: TNF-dependent synaptotoxicity contributes to the neuronal damage occurring in patients with Multiple Sclerosis (pwMS) and its mouse model Experimental Autoimmune Encephalomyelitis (EAE). Here, we investigated miR-142-3p, a synaptotoxic microRNA...
4.
Taliani V, Buonaiuto G, Desideri F, Setti A, Santini T, Galfre S, et al.
Elife
. 2023 Mar;
12.
PMID: 36877136
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently...
5.
Tsang E, Orlandini C, Sureka R, Crevenna A, Perlas E, Prankerd I, et al.
PLoS One
. 2023 Feb;
18(2):e0281464.
PMID: 36795666
The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in...
6.
Young A, Perlas E, Ruiz-Blanes N, Hierholzer A, Pomella N, Martin-Martin B, et al.
Commun Biol
. 2021 Apr;
4(1):478.
PMID: 33846535
Mutations in the gene encoding Lamin B receptor (LBR), a nuclear-membrane protein with sterol reductase activity, have been linked to rare human disorders. Phenotypes range from a benign blood disorder,...
7.
Andolina D, Di Segni M, Accoto A, Lo Iacono L, Borreca A, Ielpo D, et al.
Mol Neurobiol
. 2019 Dec;
57(1):586.
PMID: 31823196
The original version of this article unfortunately contained a mistake in Figure 3. The drawing superimposed on photomicrographs to identify the region of Dorsal raphè Nuclei was inappropriately positioned. The...
8.
Nocchi L, Portulano C, Franciosa F, Doleschall B, Panea M, Roy N, et al.
Pain
. 2019 Aug;
160(10):2305-2315.
PMID: 31365468
Nerve growth factor (NGF) and its receptors TrkA and p75 play a key role in the development and function of peripheral nociceptive neurons. Here, we describe novel technology to selectively...
9.
Nocchi L, Roy N, DAttilia M, Dhandapani R, Maffei M, Traista A, et al.
Nat Biomed Eng
. 2019 Apr;
3(2):114-125.
PMID: 30944432
Itch-a major symptom of many chronic skin diseases-can exacerbate inflammation by provoking scratching and subsequent skin damage. Here, we show that activation, via near infrared illumination, of a phototoxic agent...
10.
Dhandapani R, Arokiaraj C, Taberner F, Pacifico P, Raja S, Nocchi L, et al.
Nat Commun
. 2018 Apr;
9(1):1640.
PMID: 29691410
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary...