Emanuele Monteleone
Overview
Explore the profile of Emanuele Monteleone including associated specialties, affiliations and a list of published articles.
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16
Citations
827
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Recent Articles
1.
Fumagalli V, Rava M, Marotta D, Di Lucia P, Bono E, Giustini L, et al.
Nat Immunol
. 2024 Mar;
25(4):633-643.
PMID: 38486021
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating...
2.
Kizilirmak C, Monteleone E, Garcia-Manteiga J, Brambilla F, Agresti A, Bianchi M, et al.
iScience
. 2023 Dec;
26(12):108573.
PMID: 38144455
Transcription factor dynamics is fundamental to determine the activation of accurate transcriptional programs and yet is heterogeneous at a single-cell level, even within homogeneous populations. We asked how such heterogeneity...
3.
Mazzocca M, Loffreda A, Colombo E, Fillot T, Gnani D, Falletta P, et al.
Nat Commun
. 2023 Oct;
14(1):6433.
PMID: 37833263
Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell...
4.
Monteleone E, Corrieri P, Provero P, Viavattene D, Pulvirenti L, Raggi L, et al.
Brief Funct Genomics
. 2023 Oct;
23(5):651-662.
PMID: 37801430
Embryonic stem cells (ESCs) preserve the unique ability to differentiate into any somatic cell lineage while maintaining their self-renewal potential, relying on a complex interplay of extracellular signals regulating the...
5.
Bersani F, Picca F, Morena D, Righi L, Napoli F, Russo M, et al.
J Exp Clin Cancer Res
. 2023 May;
42(1):120.
PMID: 37170152
Background: MET-driven acquired resistance is emerging with unanticipated frequency in patients relapsing upon molecular therapy treatments. However, the determination of MET amplification remains challenging using both standard and next-generation sequencing-based...
6.
Avalle L, Raggi L, Monteleone E, Savino A, Viavattene D, Statello L, et al.
Oncogene
. 2022 Jan;
41(10):1456-1467.
PMID: 35042959
In the tumor microenvironment, Cancer Associated Fibroblasts (CAFs) become activated by cancer cells and increase their secretory activity to produce soluble factors that contribute to tumor cells proliferation, invasion and...
7.
Brambilla F, Garcia-Manteiga J, Monteleone E, Hoelzen L, Zocchi A, Agresti A, et al.
Nucleic Acids Res
. 2020 Jul;
48(16):8993-9006.
PMID: 32710624
Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair. Here, we show that in living cells nucleosomes protect DNA from...
8.
Nachmani D, Bothmer A, Grisendi S, Mele A, Bothmer D, Lee J, et al.
Nat Genet
. 2019 Oct;
51(10):1518-1529.
PMID: 31570891
RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2'-O-methylation (2'-O-Me) to...
9.
Monteleone E, Poli V
Cancer Res
. 2019 Jun;
79(12):3031-3033.
PMID: 31201166
STAT3 can mediate epigenetic silencing of tumor suppressor genes (TSG). However, little is known about the molecular mechanisms involved, except that this action is mediated by DNA methylation and requires...
10.
Lee Y, Chen M, Lee J, Zhang J, Lin S, Fu T, et al.
Science
. 2019 May;
364(6441).
PMID: 31097636
Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusive, strategy. PTEN is a critical tumor suppressive phosphatase that is active in its...