Ellen C L Willemsen
Overview
Explore the profile of Ellen C L Willemsen including associated specialties, affiliations and a list of published articles.
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9
Citations
569
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Recent Articles
1.
van der Veen S, Dijkstra J, Willemsen E, Houtman R, Milona A, Marchet N, et al.
Nucleic Acids Res
. 2024 Dec;
53(4).
PMID: 39657775
The farnesoid X receptor (FXR) is a nuclear receptor (NR) known to obligately heterodimerize with the retinoid X receptor (RXR). FXR is expressed as four isoforms (α1-α4) that drive transcription...
2.
Ijssennagger N, van Rooijen K, Magnusdottir S, Ramos Pittol J, Willemsen E, de Zoete M, et al.
JHEP Rep
. 2021 Oct;
3(5):100344.
PMID: 34604725
Background & Aims: The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from...
3.
FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs
Ramos Pittol J, Milona A, Morris I, Willemsen E, van der Veen S, Kalkhoven E, et al.
Gastroenterology
. 2020 Jul;
159(5):1853-1865.e10.
PMID: 32712104
Background & Aims: The nuclear receptor subfamily 1 group H member 4 (NR1H4, also called FXR) is a ligand-activated transcription factor that, upon binding of bile acids, regulates the expression...
4.
Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson H, et al.
Mol Metab
. 2019 Nov;
30:221-229.
PMID: 31767173
Objective: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown. Methods And Results: Here,...
5.
Massafra V, Milona A, Vos H, Ramos R, Gerrits J, Willemsen E, et al.
Gastroenterology
. 2017 Jan;
152(6):1462-1476.e10.
PMID: 28130067
Background & Aims: The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, and catabolism. FXR also regulates postprandial lipid...
6.
Bijsmans I, Milona A, Ijssennagger N, Willemsen E, Ramos Pittol J, Jonker J, et al.
Biochim Biophys Acta Mol Basis Dis
. 2016 Dec;
1863(3):687-700.
PMID: 27956139
Nuclear receptors (NRs) are ligand-activated transcription factors regulating a large variety of processes involved in reproduction, development, and metabolism. NRs are ideal drug targets because they are activated by lipophilic...
7.
Gadaleta R, Oldenburg B, Willemsen E, Spit M, Murzilli S, Salvatore L, et al.
Biochim Biophys Acta
. 2011 May;
1812(8):851-8.
PMID: 21540105
Unlabelled: Hyperactivation of NF-κB is a key factor in the pathophysiology of inflammatory bowel disease (IBD). We previously showed that the bile salt nuclear Farnesoid X Receptor (FXR) counter-regulates intestinal...
8.
Gadaleta R, van Erpecum K, Oldenburg B, Willemsen E, Renooij W, Murzilli S, et al.
Gut
. 2011 Jan;
60(4):463-72.
PMID: 21242261
Background & Aims: Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from dysregulation of the mucosal immune system and compromised intestinal epithelial barrier function. The bile salt,...
9.
Milona A, Owen B, Cobbold J, Willemsen E, Cox I, Boudjelal M, et al.
Hepatology
. 2010 Sep;
52(4):1341-9.
PMID: 20842631
Unlabelled: Pregnancy alters bile acid homeostasis and can unmask cholestatic disease in genetically predisposed but otherwise asymptomatic individuals. In this report, we show that normal pregnant mice have raised hepatic...