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Elizabeth Medlock-Kakaley

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Articles 11
Citations 195
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Recent Articles
1.
Bradley P, Romanok K, Smalling K, Gordon S, Huffman B, Paul Friedman K, et al.
Environ Int . 2024 Dec; 195():109220. PMID: 39736175
Background: Humans are primary drivers of environmental-contaminant exposures worldwide, including in drinking-water (DW). In the United States, point-of-use DW (POU-DW) is supplied via private tapwater (TW), public-supply TW, and bottled...
2.
Conley J, Lambright C, Evans N, Bangma J, Ford J, Hill D, et al.
Environ Sci Technol . 2024 Jan; 58(2):1064-1075. PMID: 38163761
Perfluoro-2-methoxyacetic acid (PFMOAA) is a short-chain perfluoroalkyl ether carboxylic acid that has been detected at high concentrations (∼10 μg/L) in drinking water in eastern North Carolina, USA, and in human...
3.
Conley J, Lambright C, Evans N, Farraj A, Smoot J, Grindstaff R, et al.
Sci Total Environ . 2023 Jun; 892:164609. PMID: 37271399
Simultaneous exposure to multiple per- and polyfluoroalkyl substances (PFAS) is common in humans across the globe. Individual PFAS are associated with adverse health effects, yet the nature of mixture effects...
4.
Conley J, Lambright C, Evans N, Medlock-Kakaley E, Dixon A, Hill D, et al.
Environ Int . 2022 Nov; 170:107631. PMID: 36402036
Globally, biomonitoring data demonstrate virtually all humans carry residues of multiple per- and polyfluoroalkyl substances (PFAS). Despite pervasive co-exposure, limited mixtures-based in vivo PFAS toxicity research has been conducted. Perfluorooctanoic...
5.
Evans N, Conley J, Cardon M, Hartig P, Medlock-Kakaley E, Gray Jr L
Toxicol Appl Pharmacol . 2022 Jun; 449:116136. PMID: 35752307
Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, additional work is needed to characterize PFAS activity on PPAR gamma (PPARγ) and other nuclear...
6.
Conley J, Lambright C, Evans N, Medlock-Kakaley E, Hill D, McCord J, et al.
Environ Int . 2021 Dec; 160:107056. PMID: 34952357
Nafion byproduct 2 (NBP2) is a polyfluoroalkyl ether sulfonic acid that was recently detected in surface water, drinking water, and human serum samples from monitoring studies in North Carolina, USA....
7.
Bradley P, Padilla I, Romanok K, Smalling K, Focazio M, Breitmeyer S, et al.
Sci Total Environ . 2021 Jun; 788:147721. PMID: 34134358
A pilot-scale expanded target assessment of mixtures of inorganic and organic contaminants in point-of-consumption drinking water (tapwater, TW) was conducted in Puerto Rico (PR) to continue to inform TW exposures...
8.
Conley J, Lambright C, Evans N, Cardon M, Medlock-Kakaley E, Wilson V, et al.
Environ Int . 2021 May; 156:106615. PMID: 34000504
Humans carry residues of multiple synthetic chemicals at any given point in time. Research has demonstrated that compounds with varying molecular initiating events (MIE) that disrupt common key events can...
9.
Conley J, Lambright C, Evans N, McCord J, Strynar M, Hill D, et al.
Environ Int . 2020 Oct; 146:106204. PMID: 33126064
Hexafluoropropylene oxide dimer acid (HFPO-DA or GenX) is an industrial replacement for the straight-chain perfluoroalkyl substance (PFAS), perfluorooctanoic acid (PFOA). Previously we reported maternal, fetal, and postnatal effects from gestation...
10.
Bradley P, Argos M, Kolpin D, Meppelink S, Romanok K, Smalling K, et al.
Sci Total Environ . 2020 Mar; 719:137236. PMID: 32126404
Safe drinking water at the point of use (tapwater, TW) is a public-health priority. TW exposures and potential human-health concerns of 540 organics and 35 inorganics were assessed in 45...