Elisabetta Brunello
Overview
Explore the profile of Elisabetta Brunello including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
885
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Recent Articles
1.
Hill C, Kalakoutis M, Arcidiacono A, Paradine Cullup F, Wang Y, Fukutani A, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(11):e2416324122.
PMID: 40073060
Muscle contraction is driven by myosin motors from the thick filaments pulling on the actin-containing thin filaments of the sarcomere, and it is regulated by structural changes in both filaments....
2.
Wang Y, Fusi L, Ovejero J, Hill C, Juma S, Paradine Cullup F, et al.
J Physiol
. 2024 Nov;
602(24):6889-6907.
PMID: 39552044
Contraction of heart muscle requires activation of both the actin and myosin filaments. The mechanism of myosin filament activation is unknown, but the leading candidate hypothesis is direct mechano-sensing by...
3.
Brunello E, Fusi L
Annu Rev Physiol
. 2023 Nov;
86():255-275.
PMID: 37931167
Force generation in striated muscle is primarily controlled by structural changes in the actin-containing thin filaments triggered by an increase in intracellular calcium concentration. However, recent studies have elucidated a...
4.
Caremani M, Fusi L, Reconditi M, Piazzesi G, Narayanan T, Irving M, et al.
J Gen Physiol
. 2023 Sep;
155(12).
PMID: 37756601
Contraction of skeletal muscle is triggered by an increase in intracellular calcium concentration that relieves the structural block on actin-binding sites in resting muscle, potentially allowing myosin motors to bind...
5.
Brunello E, Marcucci L, Irving M, Fusi L
Proc Natl Acad Sci U S A
. 2023 May;
120(22):e2302837120.
PMID: 37216507
Contraction of skeletal muscle is triggered by a transient rise in intracellular calcium concentration leading to a structural change in the actin-containing thin filaments that allows binding of myosin motors...
6.
Hill C, Brunello E, Fusi L, Ovejero J, Irving M
J Physiol
. 2022 Aug;
600(17):3983-4000.
PMID: 35912434
Myosin motors in resting muscle are inactivated by folding against the backbone of the myosin filament in an ordered helical array and must be released from that conformation to engage...
7.
Ovejero J, Fusi L, Park-Holohan S, Ghisleni A, Narayanan T, Irving M, et al.
J Gen Physiol
. 2022 Jan;
154(3).
PMID: 35089319
Myosin filament-based regulation supplements actin filament-based regulation to control the strength and speed of contraction in heart muscle. In diastole, myosin motors form a folded helical array that inhibits actin...
8.
Reconditi M, Brunello E, Fusi L, Linari M, Lombardi V, Irving M, et al.
J Gen Physiol
. 2021 Oct;
153(11).
PMID: 34668926
The myosin motors in resting skeletal muscle are folded back against their tails in the thick filament in a conformation that makes them unavailable for binding to actin. When muscles...
9.
Hill C, Brunello E, Fusi L, Ovejero J, Irving M
Elife
. 2021 Jun;
10.
PMID: 34121660
Time-resolved X-ray diffraction of isolated fast-twitch muscles of mice was used to show how structural changes in the myosin-containing thick filaments contribute to the regulation of muscle contraction, extending the...
10.
Park-Holohan S, Brunello E, Kampourakis T, Rees M, Irving M, Fusi L
Proc Natl Acad Sci U S A
. 2021 Apr;
118(16).
PMID: 33850019
Myosin-based regulation in the heart muscle modulates the number of myosin motors available for interaction with calcium-regulated thin filaments, but the signaling pathways mediating the stronger contraction triggered by stretch...