Elisabeth Sanchez-Mejias
Overview
Explore the profile of Elisabeth Sanchez-Mejias including associated specialties, affiliations and a list of published articles.
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23
Citations
1032
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Recent Articles
1.
Garcia-Alberca J, de Rojas I, Sanchez-Mejias E, Garrido-Martin D, Gonzalez-Palma L, Jimenez S, et al.
J Alzheimers Dis
. 2024 Mar;
98(2):601-618.
PMID: 38427484
Background: Microglial dysfunction plays a causative role in Alzheimer's disease (AD) pathogenesis. Here we focus on a germline insertion/deletion variant mapping SIRPβ1, a surface receptor that triggers amyloid-β(Aβ) phagocytosis via...
2.
March-Diaz R, Lara-Urena N, Romero-Molina C, Heras-Garvin A, Luis C, Alvarez-Vergara M, et al.
Nat Aging
. 2023 Apr;
1(4):385-399.
PMID: 37117599
Genetic Alzheimer's disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD...
3.
Munoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, et al.
Acta Neuropathol Commun
. 2023 Mar;
11(1):31.
PMID: 36855152
Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the contribution of nonparenchymal...
4.
Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela J, Nunez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, et al.
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628216
Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations...
5.
Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela J, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, et al.
Front Neurosci
. 2021 Nov;
15:752594.
PMID: 34803589
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological...
6.
Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon J, Nunez-Diaz C, Davila J, et al.
Neuroscientist
. 2021 Mar;
28(6):572-593.
PMID: 33769131
Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations...
7.
Sanchez-Mico M, Jimenez S, Gomez-Arboledas A, Munoz-Castro C, Romero-Molina C, Navarro V, et al.
Glia
. 2020 Dec;
69(4):997-1011.
PMID: 33283891
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, and degrade dystrophic...
8.
Garcia-Leon J, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nunez-Diaz C, Fernandez-Valenzuela J, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32962164
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer's disease (AD). The pathology of AD is very complex and still not fully understood, since different neural...
9.
Fernandez-Valenzuela J, Sanchez-Varo R, Munoz-Castro C, De Castro V, Sanchez-Mejias E, Navarro V, et al.
Sci Rep
. 2020 Sep;
10(1):14776.
PMID: 32901091
In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau leading to...
10.
Sanchez-Mejias E, Nunez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon J, Fernandez-Valenzuela J, et al.
Brain Pathol
. 2019 Sep;
30(2):345-363.
PMID: 31491047
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and aberrant...