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Eline Simons

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Recent Articles
1.
Van De Sijpe G, Gijsen M, Van der Linden L, Strouven S, Simons E, Martens E, et al.
J Med Internet Res . 2024 Nov; 26:e55185. PMID: 39602806
Background: Many patients do not receive a comprehensive medication reconciliation, mostly owing to limited resources. We hence need an approach to identify those patients at the emergency department (ED) who...
2.
Wernert F, Moparthi S, Pelletier F, Laine J, Simons E, Moulay G, et al.
Science . 2024 Aug; 385(6711):eado2032. PMID: 39172837
Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin-coated structures and endocytosis along...
3.
Simons E, Loeys B, Alaerts M
Biomedicines . 2023 Feb; 11(2). PMID: 36830871
With the discovery of induced pluripotent stem cell (iPSCs) a wide range of cell types, including iPSC-derived cardiomyocytes (iPSC-CM), can now be generated from an unlimited source of somatic cells....
4.
Sieliwonczyk E, Alaerts M, Simons E, Snyders D, Nijak A, Vandendriessche B, et al.
Orphanet J Rare Dis . 2023 Feb; 18(1):23. PMID: 36721196
Background: The c.1124_1127delTTCA p.(Ile375Argfs*43) pathogenic variant is the most frequently identified molecular defect in the KCNQ1 gene in the cardiogenetics clinic of the Antwerp University Hospital. This variant was observed...
5.
Simons E, Nijak A, Loeys B, Alaerts M
Stem Cell Res . 2022 Mar; 60:102719. PMID: 35247843
Brugada syndrome (BrS) is an inherited primary electrical disorder of the heart. 25% of BrS patients carry a mutation in the SCN5A gene, encoding the cardiac specific voltage-gated sodium channel...
6.
Nijak A, Simons E, Vandendriessche B, Van de Sande D, Fransen E, Sieliwonczyk E, et al.
Biol Open . 2022 Feb; 11(2). PMID: 35195246
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive platform for cardiovascular research. Patient-specific iPSC-CMs are very useful for studying disease development, and bear potential for disease diagnostics,...
7.
Simons E, Labro A, Saenen J, Nijak A, Sieliwonczyk E, Vandendriessche B, et al.
Eur J Med Genet . 2021 Aug; 64(11):104322. PMID: 34438094
Sudden cardiac death (SCD) is a common cause of death in young adults. In up to 80% of cases a genetic cause is suspected. Next-generation sequencing of candidate genes can...
8.
Gijsen M, Simons E, De Cock P, Malbrain M, Wauters J, Spriet I
Anaesthesiol Intensive Ther . 2021 Jul; 53(3):193-199. PMID: 34284553
Introduction: Little is known about the use of bioelectrical impedance analysis (BIA) in critically ill patients. The objective of this study was to evaluate the reproducibility of BIA measurements by...
9.
Sieliwonczyk E, Alaerts M, Robyns T, Schepers D, Claes C, Corveleyn A, et al.
Europace . 2020 Nov; 23(6):918-927. PMID: 33221854
Aims: We identified the first Belgian SCN5A founder mutation, c.4813 + 3_4813 + 6dupGGGT. To describe the clinical spectrum and disease severity associated with this mutation, clinical data of 101...
10.
Nijak A, Labro A, De Wilde H, Dewals W, Peigneur S, Tytgat J, et al.
Front Cardiovasc Med . 2020 Aug; 7:117. PMID: 32850980
Brugada syndrome (BrS) is an inherited cardiac arrhythmia with an increased risk for sudden cardiac death (SCD). About 20% of BrS cases are explained by mutations in the gene, encoding...