Elena I Deryugina
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Explore the profile of Elena I Deryugina including associated specialties, affiliations and a list of published articles.
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45
Citations
3791
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Recent Articles
1.
Kryza T, Khan T, Puttick S, Li C, Sokolowski K, Tse B, et al.
Theranostics
. 2020 Apr;
10(9):4116-4133.
PMID: 32226543
: CUB domain-containing protein 1 (CDCP1) is a cell surface receptor regulating key signalling pathways in malignant cells. CDCP1 has been proposed as a molecular target to abrogate oncogenic signalling...
2.
Deryugina E, Zajac E, Zilberberg L, Muramatsu T, Joshi G, Dabovic B, et al.
Oncogene
. 2018 Jan;
37(14):1815-1829.
PMID: 29348457
Latent transforming growth factor β (TGFβ)-binding proteins (LTBPs) are important for the secretion, activation, and function of mature TGFβ, especially so in cancer cell physiology. However, specific roles of the...
3.
Deryugina E, Kiosses W
Cell Rep
. 2017 Apr;
19(3):601-616.
PMID: 28423322
Intravasation, active entry of cancer cells into the circulation, is often considered to be a relatively late event in tumor development occurring after stromal invasion. Here, we provide evidence that...
4.
Deryugina E
Methods Mol Biol
. 2016 May;
1430:283-98.
PMID: 27172961
The mechanisms governing the development of angiogenic blood vessels, which not only deliver the nutrients to growing tumors but also provide the conduits for tumor cell dissemination, are still not...
5.
Minder P, Zajac E, Quigley J, Deryugina E
Neoplasia
. 2015 Sep;
17(8):634-49.
PMID: 26408256
Many malignant characteristics of cancer cells are regulated through pathways induced by the tyrosine kinase activity of the epidermal growth factor receptor (EGFR). Herein, we show that besides directly affecting...
6.
Deryugina E, Quigley J
Matrix Biol
. 2015 Apr;
44-46():94-112.
PMID: 25912949
Metastasis is a distinct stage of cancer progression that requires the development of angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated body of evidence indicates that...
7.
Deryugina E, Zajac E, Juncker-Jensen A, Kupriyanova T, Welter L, Quigley J
Neoplasia
. 2014 Nov;
16(10):771-88.
PMID: 25379015
According to established notion, one of the major angiogenesis-inducing factors, pro-matrix metalloproteinase-9 (proMMP-9), is supplied to the tumor microenvironment by tumor-associated macrophages (TAMs). Accumulated evidence, however, indicates that tumor-associated neutrophils...
8.
Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, et al.
Biochem J
. 2014 Nov;
465(2):259-70.
PMID: 25360794
Gelatinase B/matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) cleaves many substrates and is produced by most cell types as a zymogen, proMMP-9, in complex with the tissue inhibitor of metalloproteinases-1 (TIMP-1). Natural...
9.
Hodgson M, Deryugina E, Suarez E, Lopez S, Lin D, Xue H, et al.
Cell Commun Signal
. 2014 Sep;
12:61.
PMID: 25248616
Background: INPP4B and PTEN dual specificity phosphatases are frequently lost during progression of prostate cancer to metastatic disease. We and others have previously shown that loss of INPP4B expression correlates...
10.
Zajac E, Schweighofer B, Kupriyanova T, Juncker-Jensen A, Minder P, Quigley J, et al.
Blood
. 2013 Nov;
122(25):4054-67.
PMID: 24174628
A proangiogenic function of tissue-infiltrating monocytes/macrophages has long been attributed to their matrix metalloproteinase-9 zymogen (proMMP-9). Herein, we evaluated the capacity of human monocytes, mature M0 macrophages, and M1- and...