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Elena A Kosenko

Explore the profile of Elena A Kosenko including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 256
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Recent Articles
1.
Alilova G, Tikhonova L, Kosenko E
Biochemistry (Mosc) . 2024 Sep; 89(8):1490-1508. PMID: 39245457
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that develops in patients with severe liver dysfunction and/or portocaval shunting. Despite more than a century of research into the relationship between liver...
2.
Kosenko E, Alilova G, Tikhonova L
Biochemistry (Mosc) . 2023 Sep; 88(9):1404-1415. PMID: 37770406
Hepatic encephalopathy (HE), a neuropsychiatric disorder developing in patients with severe hepatic dysfunction, has been known for more than a century. However, pathogenetic mechanisms of cerebral dysfunction associated with liver...
3.
Protasov E, Borsakova D, Alexandrovich Y, Korotkov A, Kosenko E, Butylin A, et al.
Sci Rep . 2019 Feb; 9(1):1455. PMID: 30728433
Increased blood ammonium concentrations cause neurological complications. Existing drugs are not always sufficiently effective. Alternatively, erythrocytes-bioreactors (EBRs) loaded with enzymes utilizing ammonium, were suggested for ammonium removal from blood. However...
4.
Kosenko E, Tikhonova L, Montoliu C, Barreto G, Aliev G, Kaminsky Y
Front Neurosci . 2018 Jan; 11:728. PMID: 29354027
Alzheimer's disease (AD) is a slowly progressive, neurodegenerative disorder of uncertain etiology. According to the amyloid cascade hypothesis, accumulation of non-soluble amyloid β peptides (Aβ) in the Central Nervous System...
5.
Kosenko E, Tikhonova L, Alilova G, Montoliu C, Barreto G, Aliev G, et al.
Free Radic Biol Med . 2017 Oct; 113:109-118. PMID: 28964916
The portacaval shunting (PCS) prevents portal hypertension and recurrent bleeding of esophageal varices. On the other hand, it can induce chronic hyperammonemia and is considered to be the best model...
6.
Alexandrovich Y, Kosenko E, Sinauridze E, Obydennyi S, Kireev I, Ataullakhanov F, et al.
Biomed Res Int . 2017 Jun; 2017:5849593. PMID: 28642875
Erythrocytes (RBCs) loaded with alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALD) can metabolize plasma ethanol and acetaldehyde but with low efficiency. We investigated the rate-limiting factors in ethanol oxidation by...
7.
Kosenko E, Aliev G, Kaminsky Y
CNS Neurol Disord Drug Targets . 2015 Aug; 15(1):113-23. PMID: 26295825
Alzheimer disease (AD) is one of the most common neurodegenerative disorders widely occurring among the elderly. The pathogenic mechanisms involved in the development of this disease are still unknown. In...
8.
Kaminsky Y, Tikhonova L, Kosenko E
Front Biosci (Landmark Ed) . 2015 Jan; 20(1):173-97. PMID: 25553446
Amyloid-beta peptide (Abeta) is believed to be a central player in the Alzheimer disease (AD) pathogenesis. However, its mechanisms of toxicity to the central nervous system are unknown. To explore...
9.
Kosenko E, Tikhonova L, Reddy V, Reddy V, Aliev G, Kaminsky Y
CNS Neurol Disord Drug Targets . 2014 Aug; 13(6):1089-95. PMID: 25106624
In order to gain insight into the ammonia-detoxification mechanisms in the brain and liver tissues, we have investigated the effects of hyperammonemia in rats, in vivo, on the activity levels...
10.
Tikhonova L, Kaminsky Y, Reddy V, Li Y, Solomadin I, Kosenko E, et al.
Am J Alzheimers Dis Other Demen . 2014 May; 29(8):685-95. PMID: 24838531
Amyloid β25-35 (Aβ25-35) represents a neurotoxic fragment of Aβ1-40 or Aβ1-42, and is implicated in the progressive neurodegeneration in cases of the Alzheimer disease (AD). Amyloid β25-35 was shown to...