Eleftheria Maratos-Flier
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Explore the profile of Eleftheria Maratos-Flier including associated specialties, affiliations and a list of published articles.
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99
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9812
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Recent Articles
1.
Smith W, Nguyen D, Clough T, Schofield J, Kagan M, Kompa J, et al.
J Clin Endocrinol Metab
. 2024 Aug;
110(3):771-786.
PMID: 39148430
Background: Growth differentiation factor 15 (GDF15), a divergent member of the TGF-β superfamily, signals via the hindbrain glial-derived neurotrophic factor receptor alpha-like and rearranged during transfection receptor co-receptor (GFRAL-RET) complex....
2.
Ma Y, Singhal G, Chan S, Wang C, Yu H, Yin B, et al.
Liver Int
. 2024 Mar;
44(7):1668-1679.
PMID: 38554044
Background: Liver ischaemia/reperfusion (I/R) injury, which is an inevitable clinical problem of liver resection, liver transplantation and haemorrhagic shock. Fibroblast growth factor 21 (FGF21) was intimately coupled with multiple metabolic...
3.
Panella R, Petri A, Desai B, Fagoonee S, Cotton C, Nguyen P, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37629051
Obesity is a growing public health problem associated with increased risk of type 2 diabetes, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD) and cancer. Here, we identify microRNA-22 (miR-22) as...
4.
Rodgers M, Migdal A, Ghorbani Rodriguez T, Chen Z, Nath A, Gerszten R, et al.
Front Endocrinol (Lausanne)
. 2021 Dec;
12:742873.
PMID: 34867786
Objective: As there is significant heterogeneity in the weight loss response to pharmacotherapy, one of the most important clinical questions in obesity medicine is how to predict an individual's response...
5.
Rader D, Maratos-Flier E, Nguyen A, Hom D, Ferriere M, Li Y, et al.
J Clin Endocrinol Metab
. 2021 Aug;
107(1):e57-e70.
PMID: 34431493
Purpose: To evaluate the safety and potential efficacy of LLF580, a genetically engineered variant of human fibroblast growth factor-21, for triglyceride lowering, weight loss, and hepatic fat reduction. Methods: A...
6.
Sandhu B, Perez-Matos M, Tran S, Singhal G, Syed I, Feldbrugge L, et al.
Metabolism
. 2021 Feb;
118:154731.
PMID: 33631144
Background: Ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), also known as CD39L3, is the dominant ectonucleotidase expressed by beta cells in the islet of Langerhans and on nerves. NTPDase3 catalyzes the conversion...
7.
Watanabe M, Singhal G, Fisher F, Beck T, Morgan D, Socciarelli F, et al.
Endocrine
. 2019 Nov;
67(1):95-108.
PMID: 31728756
Background: Fibroblast growth factor 21 (FGF21) is expressed in several metabolically active tissues, including liver, fat, and acinar pancreas, and has pleiotropic effects on metabolic homeostasis. The dominant source of...
8.
Chee M, Hebert A, Briancon N, Flaherty 3rd S, Pissios P, Maratos-Flier E
Mol Metab
. 2019 Nov;
29:114-123.
PMID: 31668382
Objective: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated...
9.
Singhal G, Kumar G, Chan S, Fisher F, Ma Y, Vardeh H, et al.
Mol Metab
. 2018 May;
13:56-66.
PMID: 29753678
Objective: Non-alcoholic fatty liver (NAFL) associated with obesity is a major cause of liver diseases which can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Fibroblast growth factor 21...
10.
Ter Horst K, Gilijamse P, Demirkiran A, van Wagensveld B, Ackermans M, Verheij J, et al.
Mol Metab
. 2017 Nov;
6(11):1493-1502.
PMID: 29107295
Objective: Fructose consumption has been implicated in the development of obesity and insulin resistance. Emerging evidence shows that fibroblast growth factor 21 (FGF21) has beneficial effects on glucose, lipid, and...