Elaine Spain
Overview
Explore the profile of Elaine Spain including associated specialties, affiliations and a list of published articles.
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17
Citations
167
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Recent Articles
1.
Adamson K, Spain E, Prendergast U, Forster R, Moran N, Keyes T
Biomater Sci
. 2020 Jun;
2(10):1509-1520.
PMID: 32481925
Blood platelet adhesion is crucial in dictating haemocompatibility of medical implants and in platelet capture in diagnostics. Understanding the role of platelet activation in dictating platelet adhesion at chemically modified...
2.
McArdle H, Hogg M, Bauer S, Rosenow F, Prehn J, Adamson K, et al.
Sci Rep
. 2020 May;
10(1):7516.
PMID: 32371908
Elevated levels of transfer RNA (tRNA) fragments were recently identified in plasma samples from people with epilepsy in advance of a seizure, indicting a potential novel class of circulating biomarker....
3.
Kenny A, McArdle H, Calero M, Rabano A, Madden S, Adamson K, et al.
Biomolecules
. 2019 Nov;
9(11).
PMID: 31766231
The need for practical biomarkers for early diagnosis of Alzheimer's disease (AD) remains largely unmet. Here we investigated the use of blood-based microRNAs as prognostic biomarkers for AD and their...
4.
Spain E, Carrara S, Adamson K, Ma H, OKennedy R, De Cola L, et al.
ACS Omega
. 2019 Aug;
3(12):17116-17124.
PMID: 31458332
An electrochemical biosensor for the detection of cardiac troponin I, cTnI, an important cardiac biomarker, is described. A combination of a novel monoclonal antibody, mAb20B3, and a novel Ir(III)-based metal...
5.
Raoof R, Bauer S, Naggar H, Connolly N, Brennan G, Brindley E, et al.
EBioMedicine
. 2018 Nov;
38:127-141.
PMID: 30396857
Background: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression,...
6.
Adamson K, Spain E, Prendergast U, Moran N, Forster R, Keyes T
Langmuir
. 2017 Dec;
34(2):715-725.
PMID: 29240434
Human blood platelets and SK-N-AS neuroblastoma cancer-cell capture at spontaneously adsorbed monolayers of fibrinogen-binding motifs, GRGDS (generic integrin adhesion), HHLGGAKQAGDV (exclusive to platelet integrin αβ), or octanethiol (adhesion inhibitor) at...
7.
McArdle H, Jimenez-Mateos E, Raoof R, Carthy E, Boyle D, ElNaggar H, et al.
Sci Rep
. 2017 May;
7(1):1750.
PMID: 28496112
Diagnosis of seizure disorders such as epilepsy currently relies on clinical examination and electroencephalogram recordings and is associated with substantial mis-diagnosis. The miRNA, miR-134 (MIR134 in humans), has been found...
8.
Spain E, Adamson K, Elshahawy M, Bray I, Keyes T, Stallings R, et al.
Analyst
. 2017 Jan;
142(5):752-762.
PMID: 28091676
Defects within a self-assembled monolayer (SAM) of dodecanethiol on gold have been used as nucleation sites for the electrodeposition of mushroom shaped platinum nanoparticles (PtNPs). The top surfaces of these...
9.
Adamson K, Spain E, Prendergast U, Moran N, Forster R, Keyes T
ACS Appl Mater Interfaces
. 2016 Dec;
8(47):32189-32201.
PMID: 27933817
Ordered spherical cap gold cavity arrays with 5.4, 1.6, and 0.98 μm diameter apertures were explored as capture surfaces for human blood platelets to investigate the impact of surface geometry...
10.
Spain E, Gilgunn S, Sharma S, Adamson K, Carthy E, OKennedy R, et al.
Biosens Bioelectron
. 2015 Oct;
77:759-66.
PMID: 26513282
Highly sensitive and label free detection of prostate specific antigen (PSA) still remains a challenge in prostate cancer diagnosis. In this paper, we propose a sensitive electrochemical immunosensor based on...