El-Ad David Amir
Overview
Explore the profile of El-Ad David Amir including associated specialties, affiliations and a list of published articles.
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16
Citations
3128
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0
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Recent Articles
1.
Imanishi M, Cheng H, Kotla S, Deswal A, Le N, Chini E, et al.
Front Cardiovasc Med
. 2022 Nov;
9:988713.
PMID: 36426217
Radiation therapy (RT) to the chest increases the patients' risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive,...
2.
Steele N, Carpenter E, Kemp S, Sirihorachai V, The S, Delrosario L, et al.
Nat Cancer
. 2021 Jul;
1(11):1097-1112.
PMID: 34296197
Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor microenvironment that renders it largely refractory to immunotherapy. We implemented a multimodal analysis approach to elucidate the immune landscape in...
3.
Fernandez D, Rahman A, Fernandez N, Chudnovskiy A, Amir E, Amadori L, et al.
Nat Med
. 2019 Oct;
25(10):1576-1588.
PMID: 31591603
Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. However, specific characteristics of dysregulated immune cells within atherosclerotic lesions that lead...
4.
Lee B, Kelly G, Bradford S, Davila M, Guo X, Amir E, et al.
Cytometry A
. 2019 Aug;
95(9):1019-1030.
PMID: 31364278
Mass cytometry is a powerful tool for high-dimensional single cell characterization. Since the introduction of the first commercial CyTOF mass cytometer by DVS Sciences in 2009, mass cytometry technology has...
5.
Amir E, Lee B, Badoual P, Gordon M, Guo X, Merad M, et al.
Front Immunol
. 2019 Jun;
10:1315.
PMID: 31244854
Large-scale immune monitoring experiments (such as clinical trials) are a promising direction for biomarker discovery and responder stratification in immunotherapy. Mass cytometry is one of the tools in the immune...
6.
Wroblewska A, Dhainaut M, Ben-Zvi B, Rose S, Park E, Amir E, et al.
Cell
. 2018 Oct;
175(4):1141-1155.e16.
PMID: 30343902
CRISPR pools are being widely employed to identify gene functions. However, current technology, which utilizes DNA as barcodes, permits limited phenotyping and bulk-cell resolution. To enable novel screening capabilities, we...
7.
Michlmayr D, Pak T, Rahman A, Amir E, Kim E, Kim-Schulze S, et al.
Mol Syst Biol
. 2018 Aug;
14(8):e7862.
PMID: 30150281
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes global epidemics of debilitating disease worldwide. To gain functional insight into the host cellular genes required for virus infection, we performed...
8.
Amir E, Guo X, Mayovska O, Rahman A
J Immunol Methods
. 2017 Sep;
453:20-29.
PMID: 28882613
High dimensional cytometry now allows measurement of over 50 parameters in a single sample, and is typically visualized using sophisticated dimensionality-reducing methods and analyzed with automated clustering algorithms. While these...
9.
Lavin Y, Kobayashi S, Leader A, Amir E, Elefant N, Bigenwald C, et al.
Cell
. 2017 May;
169(4):750-765.e17.
PMID: 28475900
To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma...
10.
Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramirez J, Rahman A, et al.
Cell
. 2016 Oct;
167(2):444-456.e14.
PMID: 27716507
While conventional pathogenic protists have been extensively studied, there is an underappreciated constitutive protist microbiota that is an integral part of the vertebrate microbiome. The impact of these species on...