Eiichi Kumamoto
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Explore the profile of Eiichi Kumamoto including associated specialties, affiliations and a list of published articles.
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59
Citations
711
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Recent Articles
1.
Kumamoto E
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766326
Nociceptive information is transmitted by action potentials (APs) through primary afferent neurons from the periphery to the central nervous system. Voltage-gated Na channels are involved in this AP production, while...
2.
Kumamoto E
Pharmaceuticals (Basel)
. 2020 Apr;
13(4).
PMID: 32260535
Nociceptive information is transmitted from the periphery to the cerebral cortex mainly by action potential (AP) conduction in nerve fibers and chemical transmission at synapses. Although this nociceptive transmission is...
3.
Kumamoto E
Pharmaceuticals (Basel)
. 2019 Sep;
12(3).
PMID: 31527474
Much evidence indicates that hypothalamus-derived neuropeptides, oxytocin, orexins A and B, inhibit nociceptive transmission in the rat spinal dorsal horn. In order to unveil cellular mechanisms for this antinociception, the...
4.
Koga A, Fujita T, Piao L, Nakatsuka T, Kumamoto E
Mol Pain
. 2019 Feb;
15:1744806918824243.
PMID: 30799694
To reveal cellular mechanisms for antinociception produced by clinically used tramadol, we investigated the effect of its metabolite O-desmethyltramadol (M1) on glutamatergic excitatory transmission in spinal dorsal horn lamina II...
5.
Magori N, Fujita T, Mizuta K, Kumamoto E
Naunyn Schmiedebergs Arch Pharmacol
. 2018 Dec;
392(3):359-369.
PMID: 30519707
Although the intravenous general anesthetic propofol (2,6-diisopropylphenol) has an ability to inhibit nerve conduction, this has not been fully examined. Various agents inhibit compound action potentials (CAPs) in a manner...
6.
Wang C, Yu T, Fujita T, Kumamoto E
Pharmacol Rep
. 2018 Nov;
71(1):67-72.
PMID: 30471518
Background: Transient receptor potential ankyrin-1 (TRPA1) channels expressed in the central terminal of dorsal root ganglion neurons in the spinal substantia gelatinosa (SG) play a role in modulating nociceptive transmission....
7.
Wang C, Fujita T, Kumamoto E
Neuroscience
. 2018 May;
383:114-128.
PMID: 29752983
Cellular mechanisms underlying the antinociceptive properties of orexins, a group of neuropeptides produced by the hypothalamus, in the spinal dorsal horn have not been thoroughly investigated. We examined how orexin...
8.
Wang C, Fujita T, Kumamoto E
Biochem Biophys Res Commun
. 2018 Apr;
501(1):100-105.
PMID: 29705705
Hypothalamic neuropeptides, orexins A and B, differently inhibit nociceptive behavior. This difference is possibly due to a distinction between orexins A and B in modulating synaptic transmission in spinal substantia...
9.
Suzuki R, Fujita T, Mizuta K, Kumamoto E
Biomed Pharmacother
. 2018 Apr;
103:326-335.
PMID: 29665554
Aims: Although antinociception produced by non-steroidal anti-inflammatory drugs (NSAIDs) is partly attributed to nerve conduction inhibition, this has not been thoroughly examined yet. The aim of the present study was...
10.
Magori N, Fujita T, Kumamoto E
Eur J Pharmacol
. 2017 Dec;
819:254-260.
PMID: 29225186
Hinokitiol (β-thujaplicin) is a natural tropolone derivative contained in Chamaecyparis taiwanensis that has various actions including anti-inflammatory activities. Various plant-derived compounds inhibit compound action potentials (CAPs) in a manner dependent...