Ehesan U Sharif
Overview
Explore the profile of Ehesan U Sharif including associated specialties, affiliations and a list of published articles.
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13
Citations
113
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Recent Articles
1.
Mata G, Miles D, Drew S, Fournier J, Lawson K, Mailyan A, et al.
J Med Chem
. 2021 Oct;
65(2):1418-1444.
PMID: 34672584
Phosphoinositide-3-kinase γ (PI3Kγ) is highly expressed in immune cells and promotes the production and migration of inflammatory mediators. The inhibition of PI3Kγ has been shown to repolarize the tumor immune...
2.
Sharif E, Kalisiak J, Lawson K, Miles D, Newcomb E, Lindsey E, et al.
J Med Chem
. 2021 Jan;
64(1):845-860.
PMID: 33399453
Solid tumors are often associated with high levels of extracellular ATP. Ectonucleotidases catalyze the sequential hydrolysis of ATP to adenosine, which potently suppresses T-cell and NK-cell functions via the adenosine...
3.
Miles D, Yan X, Thomas-Tran R, Fournier J, Sharif E, Drew S, et al.
ACS Med Chem Lett
. 2020 Nov;
11(11):2244-2252.
PMID: 33214836
The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated...
4.
Drew S, Thomas-Tran R, Beatty J, Fournier J, Lawson K, Miles D, et al.
J Med Chem
. 2020 Sep;
63(19):11235-11257.
PMID: 32865410
The selective inhibition of the lipid signaling enzyme PI3Kγ constitutes an opportunity to mediate immunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due to the high...
5.
Lawson K, Kalisiak J, Lindsey E, Newcomb E, Leleti M, Debien L, et al.
J Med Chem
. 2020 Jul;
63(20):11448-11468.
PMID: 32614585
Extracellular adenosine (ADO), present in high concentrations in the tumor microenvironment (TME), suppresses immune function via inhibition of T cell and NK cell activation. Intratumoral generation of ADO depends on...
6.
Trost B, Xu S, Sharif E
J Am Chem Soc
. 2019 Jun;
141(26):10199-10204.
PMID: 31194521
Pyrimidine nucleosides are an important class of compounds with versatile applications across many fields, including biology and medicinal chemistry. Synthesis of nucleoside analogs in optically pure form via traditional glycosylation...
7.
Trost B, Sharif E, Cregg J
Chem Sci
. 2017 Apr;
8(1):770-774.
PMID: 28451225
Efficient synthesis of versatile building blocks for enabling medicinal chemistry research has always challenged synthetic chemists to develop innovative methods. Of particular interest are the methods that are amenable to...
8.
Trost B, Koester D, Sharif E
Chemistry
. 2015 Dec;
22(8):2634-8.
PMID: 26669265
The synthesis of densly functionized α-silyl-β-hydroxyl vinylsilanes via ruthenium-catalyzed multicomponent reaction (MCR) is reported herein. Exceptionally high regio- and diastereoselectivity was achieved by employing an unprecedented hydrosilylation of bifunctional silyl-propargyl...
9.
Bajaj S, Sharif E, Akhmedov N, ODoherty G
Chem Sci
. 2015 Mar;
5(6):2230-2234.
PMID: 25729559
The first synthesis of any and all members of the mezzettiaside family of natural products has been achieved. The reported synthesis features the iterative use of the Taylor catalyst in...
10.
Sharif E, ODoherty G
European J Org Chem
. 2013 Dec;
2012(11).
PMID: 24371430
Jadomycins are unique angucycline polyketides, which are produced by soil bacteria under specific nutrient and environmental conditions. Their unique structural complexity and biological activities have engendered extensive study of the...