Edwin W Rubel
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Explore the profile of Edwin W Rubel including associated specialties, affiliations and a list of published articles.
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116
Citations
4622
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Recent Articles
1.
Wu P, Barros-Becker F, Ogelman R, Camci E, Linbo T, Simon J, et al.
Front Neurol
. 2024 Nov;
15:1480435.
PMID: 39610699
Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is...
2.
Wu P, Becker F, Ogelman R, Camci E, Linbo T, Simon J, et al.
bioRxiv
. 2024 Jul;
PMID: 39005374
Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is...
3.
Bellairs J, Redila V, Wu P, Tong L, Webster A, Simon J, et al.
Front Mol Neurosci
. 2022 Aug;
15:944846.
PMID: 35923755
There are no approved therapeutics for the prevention of hearing loss and vestibular dysfunction from drugs like aminoglycoside antibiotics. While the mechanisms underlying aminoglycoside ototoxicity remain unresolved, there is considerable...
4.
Davis S, Wu P, Camci E, Simon J, Rubel E, Raible D
Hear Res
. 2020 Aug;
395:108019.
PMID: 32768772
Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in...
5.
Kitcher S, Kirkwood N, Camci E, Wu P, Gibson R, Redila V, et al.
JCI Insight
. 2019 Aug;
4(15).
PMID: 31391343
Aminoglycoside (AG) antibiotics are widely used to prevent life-threatening infections, and cisplatin is used in the treatment of various cancers, but both are ototoxic and result in loss of sensory...
6.
Stawicki T, Linbo T, Hernandez L, Parkinson L, Bellefeuille D, Rubel E, et al.
Biol Open
. 2018 Dec;
8(1).
PMID: 30578252
Sensory hair cells are susceptible to numerous insults, including certain therapeutic medications like aminoglycoside antibiotics, and hearing and balance disorders are often a dose-limiting side effect of these medications. We...
7.
Bhandiwad A, Raible D, Rubel E, Sisneros J
J Assoc Res Otolaryngol
. 2018 Sep;
19(6):741-752.
PMID: 30191425
Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5-7 days post-fertilization)...
8.
Zorio D, Monsma S, Sanes D, Golding N, Rubel E, Wang Y
Genomics
. 2018 Mar;
111(3):441-449.
PMID: 29526484
The Mongolian gerbil (Meriones unguiculatus) is a member of the rodent family that displays several features not found in mice or rats, including sensory specializations and social patterns more similar...
9.
Chowdhury S, Owens K, Herr R, Jiang Q, Chen X, Johnson G, et al.
J Med Chem
. 2017 Oct;
61(1):84-97.
PMID: 28992413
Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells, a robust model for mammalian auditory and vestibular...
10.
Sakano H, Zorio D, Wang X, Ting Y, Noble W, MacCoss M, et al.
J Comp Neurol
. 2017 Jul;
525(15):3341-3359.
PMID: 28685837
The avian nucleus laminaris (NL) is a brainstem nucleus necessary for binaural processing, analogous in structure and function to the mammalian medial superior olive. In chickens (Gallus gallus), NL is...