Edward P Ingenito
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Explore the profile of Edward P Ingenito including associated specialties, affiliations and a list of published articles.
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51
Citations
1763
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Recent Articles
1.
Taylor-Cousar J, Munck A, McKone E, van der Ent C, Moeller A, Simard C, et al.
N Engl J Med
. 2017 Nov;
377(21):2013-2023.
PMID: 29099344
Background: Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic...
2.
Rowe S, Daines C, Ringshausen F, Kerem E, Wilson J, Tullis E, et al.
N Engl J Med
. 2017 Nov;
377(21):2024-2035.
PMID: 29099333
Background: Cystic fibrosis is an autosomal recessive disease caused by mutations in the CFTR gene that lead to progressive respiratory decline. Some mutant CFTR proteins show residual function and respond...
3.
Busse W, Holgate S, Wenzel S, Klekotka P, Chon Y, Feng J, et al.
Chest
. 2015 Jul;
148(6):1489-1496.
PMID: 26226215
Background: High bronchodilator reversibility in adult asthma is associated with distinct clinical characteristics. This analysis compares lung function, biomarker profiles, and disease control in patients with high reversibility (HR) and...
4.
Thane K, Ingenito E, Hoffman A
Transl Res
. 2013 Dec;
163(4):363-76.
PMID: 24316173
Lung regeneration research is yielding data with increasing translational value. The classical models of lung development, postnatal alveolarization, and postpneumonectomy alveolarization have contributed to a broader understanding of the cellular...
5.
Paxson J, Gruntman A, Davis A, Parkin C, Ingenito E, Hoffman A
Stem Cells Dev
. 2013 Jul;
22(24):3214-25.
PMID: 23895415
Aging is a critical determinant of regenerative capacity in many organ systems, but it remains unresolved in the lung. This study examines murine lung cell dynamics during age-dependent lung regeneration....
6.
Valipour A, Kramer M, Stanzel F, Kempa A, Asadi S, Fruchter O, et al.
Front Physiol
. 2012 Oct;
3:387.
PMID: 23060811
Rationale: In clinical trials, homogeneous emphysema patients have responded well to upper lobe volume reduction but not lower lobe volume reduction. Materials/methods: To understand the physiological basis for this observation,...
7.
Peter Y, Sen N, Levantini E, Keller S, Ingenito E, Ciner A, et al.
J Tissue Eng Regen Med
. 2012 May;
7(7):572-83.
PMID: 22585451
Compensatory growth is mediated by multiple cell types that interact during organ repair. To elucidate the relationship between stem/progenitor cells that proliferate or differentiate and somatic cells of the lung,...
8.
Paxson J, Gruntman A, Parkin C, Mazan M, Davis A, Ingenito E, et al.
PLoS One
. 2011 Sep;
6(8):e23232.
PMID: 21912590
While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We...
9.
Hoffman A, Paxson J, Mazan M, Davis A, Tyagi S, Murthy S, et al.
Stem Cells Dev
. 2011 May;
20(10):1779-92.
PMID: 21585237
While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-MSCs), there is very limited data on their biological properties and therapeutic potential in vivo. How L-MSCs compare...
10.
Herth F, Eberhardt R, Ingenito E, Gompelmann D
Expert Rev Med Devices
. 2011 May;
8(3):307-12.
PMID: 21542703
AeriSeal Emphysematous Lung Sealant is a novel endoscopic lung-volume reduction therapy designed to reduce hyperinflation and improve pulmonary function and quality of life in patients with advanced emphysema. The device...