Edward C Lisic
Overview
Explore the profile of Edward C Lisic including associated specialties, affiliations and a list of published articles.
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4
Citations
12
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Recent Articles
1.
Jiang X, Fielding L, Davis H, Carroll W, Lisic E, Deweese J
Int J Mol Sci
. 2023 Aug;
24(15).
PMID: 37569386
Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effects of thiosemicarbazones (TSC) and metal-TSC complexes...
2.
Keck J, Conner J, Wilson J, Jiang X, Lisic E, Deweese J
Chem Res Toxicol
. 2019 Sep;
32(10):2135-2143.
PMID: 31512855
Topoisomerase II is a nuclear enzyme involved in the maintenance of DNA and is an effective anticancer drug target. However, several clinical topoisomerase II-targeted agents display significant off-target toxicities and...
3.
Morris W, Ngo L, Wilson J, Medawala W, Brown A, Conner J, et al.
Chem Res Toxicol
. 2018 Nov;
32(1):90-99.
PMID: 30484632
Our previous research has shown that α-(N)-heterocyclic thiosemicarbazone (TSC) metal complexes inhibit human topoisomerase IIα (TopoIIα), while the ligands without metals do not. To find out the structural elements of...
4.
Wilson J, Jiang X, McGill B, Lisic E, Deweese J
Chem Res Toxicol
. 2016 Mar;
29(4):649-58.
PMID: 26982206
Type II DNA topoisomerases resolve topological knots and tangles in DNA that result from routine cellular processes and are effective targets for anticancer therapeutics. To this end, thiosemicarbazones have been...