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Eduardo Aliprandini

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Recent Articles
1.
Aguirre-Botero M, Pacios O, Celli S, Aliprandini E, Gladston A, Thiberge J, et al.
Elife . 2025 Feb; 14. PMID: 39951341
sporozoites are inoculated into the skin during the bite of an infected mosquito. This motile stage invades cutaneous blood vessels to reach the liver and infect hepatocytes. The circumsporozoite protein...
2.
Aguirre-Botero M, Aliprandini E, Gladston A, Pacios O, Martins R, Poyet J, et al.
Microorganisms . 2024 Mar; 12(3). PMID: 38543531
Membranolytic molecules constitute the first line of innate immune defense against pathogenic microorganisms. sporozoites are potentially exposed to these cytotoxic molecules in the hemolymph and salivary glands of mosquitoes, as...
3.
Zmarlak N, Lavazec C, Brito-Fravallo E, Geneve C, Aliprandini E, Aguirre-Botero M, et al.
PLoS Pathog . 2024 Feb; 20(2):e1012008. PMID: 38354186
Leucine-rich repeat (LRR) proteins are commonly involved in innate immunity of animals and plants, including for pattern recognition of pathogen-derived elicitors. The Anopheles secreted LRR proteins APL1C and LRIM1 are...
4.
Aguirre-Botero M, Wang L, Formaglio P, Aliprandini E, Thiberge J, Schon A, et al.
Cell Rep . 2023 Jun; 42(7):112681. PMID: 37389992
Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for preventing malaria infection. However, their mechanisms of protection remain unclear....
5.
Nacer A, Kivi G, Pert R, Juronen E, Holenya P, Aliprandini E, et al.
Front Cell Infect Microbiol . 2022 Jul; 12:901253. PMID: 35782147
Malaria, an infection caused by apicomplexan parasites of the genus , continues to exact a significant toll on public health with over 200 million cases world-wide, and annual deaths in...
6.
Lima L, Marques R, Gimenez A, Francoso K, Aliprandini E, Camargo T, et al.
Microorganisms . 2020 Jun; 8(6). PMID: 32560380
Infections with are predominant in the Americas, representing 75% of malaria cases. Previously perceived as benign, malaria vivax is, in fact, a highly debilitating and economically important disease. Considering the...
7.
Aliprandini E, Takata D, Lepique A, Kalil J, Boscardin S, Moro A
Toxicon X . 2020 Jun; 2:100006. PMID: 32550563
The use of antibody-based therapy to treat a variety of diseases and conditions is well documented. The use of antibodies as an antidote to treat tetanus infections was one of...
8.
Marques R, Gimenez A, Aliprandini E, Novais J, Cury D, Watanabe I, et al.
Vaccines (Basel) . 2020 Apr; 8(2). PMID: 32325874
is the most common species of human malaria parasite found outside Africa, with high endemicity in Asia, Central and South America, and Oceania. Although causes the majority of deaths, can...
9.
Mura M, Ruffie C, Combredet C, Aliprandini E, Formaglio P, Chitnis C, et al.
NPJ Vaccines . 2019 Mar; 4:12. PMID: 30820355
Following the RTS,S malaria vaccine, which showed only partial protection with short-term memory, there is strong support to develop second-generation malaria vaccines that yield higher efficacy with longer duration. The...
10.
Aliprandini E, Tavares J, Panatieri R, Thiberge S, Yamamoto M, Silvie O, et al.
Nat Microbiol . 2018 Oct; 3(11):1224-1233. PMID: 30349082
The circumsporozoite protein (CSP) is the major surface protein of malaria sporozoites (SPZs), the motile and invasive parasite stage inoculated in the host skin by infected mosquitoes. Antibodies against the...