Edmund Kwok-Kwan Tung
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Explore the profile of Edmund Kwok-Kwan Tung including associated specialties, affiliations and a list of published articles.
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12
Citations
424
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Recent Articles
1.
Tsui Y, Sze K, Tung E, Ho D, Lee T, Ng I
Oncotarget
. 2017 Apr;
8(24):39430-39442.
PMID: 28455968
Dishevelled-3 (Dvl3) is regarded as a binding hub with many different interacting partners. However, its regulation and mechanism on cancer stemness remain to be explored. In this study, we showed...
2.
Leung C, Chak-Lui Wong C, Fan D, Kai A, Tung E, Xu I, et al.
Oncotarget
. 2015 Apr;
6(13):10880-92.
PMID: 25834102
Hepatocellular carcinoma (HCC) is characteristically one of the most rapidly proliferating tumors which outgrows functional blood supply and results in regional oxygen deprivation. Overexpression of PIM1, a serine/threonine kinase, has...
3.
Tung E, Ng I
Future Oncol
. 2012 Dec;
8(12):1525-8.
PMID: 23231514
Hyperactivation of the Wnt/β-catenin signaling pathway has been implicated in cancers, including hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is a secretory antagonist of the Wnt/β-catenin signaling pathway and has been found...
4.
Ma W, Chak-Lui Wong C, Tung E, Wong C, Ng I
Hepatology
. 2012 Jul;
57(1):152-61.
PMID: 22829315
Unlabelled: Deregulation of Rho guanosine triphosphatase (GTPase) pathways plays an important role in tumorigenesis and metastasis of hepatocellular carcinoma (HCC). RhoE/Rnd3 belongs to an atypical subfamily of the RhoGTPase, the...
5.
Tung E, Wong B, Yau T, Ng I
PLoS One
. 2012 May;
7(5):e36565.
PMID: 22570728
Background: Activation of the Wnt/β-catenin signaling pathway plays a crucial role in hepatocellular carcinoma (HCC). Low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) is one of the co-receptors of the Wnt/β-catenin pathway...
6.
Tung E, Mak C, Fatima S, Lo R, Zhao H, Zhang C, et al.
Liver Int
. 2011 Sep;
31(10):1494-504.
PMID: 21955977
Background: Although Dickkopf-1 (DKK1) is known to be a negative regulator of the Wnt/β-catenin pathway, it has been recently found to be upregulated in cancers. Aims: We investigated the clinical...
7.
Gao P, Chak-Lui Wong C, Tung E, Lee J, Wong C, Ng I
J Hepatol
. 2010 Dec;
54(6):1177-84.
PMID: 21145831
Background & Aims: Deregulation of microRNAs (miRNAs) plays an important role in human carcinogenesis. However, miRNA deregulation in the pre-malignant lesions and expression changes during multistep hepatocarcinogenesis remain elusive. Methods:...
8.
Ko F, Chan L, Tung E, Lowe S, Ng I, Yam J
Gastroenterology
. 2010 Jul;
139(4):1397-407.
PMID: 20600027
Background & Aims: Deleted in liver cancer 1 (DLC1), which encodes a Rho GTPase activating protein, is a bona fide tumor suppressor in hepatocellular carcinoma. Underexpression of DLC1 in cancer...
9.
Hui I, Tung E, Sze K, Ching Y, Ng I
Liver Int
. 2009 Oct;
30(1):65-75.
PMID: 19845851
Background: The mammalian target of rapamycin (mTOR), which phosphorylates p70S6K and 4EBP1 and activates the protein translation process, is upregulated in cancers and its activation may be involved in cancer...
10.
Chak-Lui Wong C, Wong C, Tung E, Man K, Ng I
Hepatology
. 2009 Feb;
49(5):1583-94.
PMID: 19205033
Unlabelled: Deregulation of Rho family small guanosine triphosphatases has been implicated in human carcinogenesis. Rho-kinases are downstream effectors of Rho guanosine triphosphatases in the regulation of cytoskeletal reorganization and cell...