Edgar Bernardo
Overview
Explore the profile of Edgar Bernardo including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
270
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Recent Articles
1.
Miguel-Escalada I, Maestro M, Balboa D, Elek A, Bernal A, Bernardo E, et al.
Dev Cell
. 2022 Aug;
57(16):1922-1936.e9.
PMID: 35998583
Sequence variants in cis-acting enhancers are important for polygenic disease, but their role in Mendelian disease is poorly understood. Redundancy between enhancers that regulate the same gene is thought to...
2.
Diaz-Chamorro S, Garrido-Jimenez S, Barrera-Lopez J, Mateos-Quiros C, Cumplido-Laso G, Lorenzo M, et al.
Front Cell Dev Biol
. 2022 Feb;
9:708844.
PMID: 35111744
IL6 is an essential cytokine in metabolism regulation and for intercommunication among different organs and tissues. IL6 produced by different tissues has different functions and therefore it is very important...
3.
Torres J, Usategui-Martin R, Hernandez-Cosido L, Bernardo E, Manzanedo-Bueno L, Hernandez-Garcia I, et al.
J Gastrointest Surg
. 2021 Dec;
26(2):286-297.
PMID: 34882294
Background: The peroxisome proliferator-activated receptor (PPAR)-γ plays a key role in adipose tissue differentiation and fat metabolism. However, it is unclear which factors may regulate its expression and whether obese...
4.
Ghose R, Aranguren-Ibanez A, Arecco N, Balboa D, Bataller M, Beltran S, et al.
F1000Res
. 2021 Nov;
9:1336.
PMID: 34745570
The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a...
5.
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer
Kalisz M, Bernardo E, Beucher A, Maestro M, Del Pozo N, Millan I, et al.
EMBO J
. 2020 Mar;
39(9):e102808.
PMID: 32154941
Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encoding the transcription factor HNF1A harbors susceptibility...
6.
Matesanz N, Nikolic I, Leiva M, Pulgarin-Alfaro M, Santamans A, Bernardo E, et al.
PLoS Biol
. 2018 Jul;
16(7):e2004455.
PMID: 29979672
Adipose tissue has emerged as an important regulator of whole-body metabolism, and its capacity to dissipate energy in the form of heat has acquired a special relevance in recent years...
7.
Matesanz N, Bernardo E, Acin-Perez R, Manieri E, Perez-Sieira S, Hernandez-Cosido L, et al.
Nat Commun
. 2017 Oct;
8(1):856.
PMID: 29021624
Increasing the thermogenic capacity of adipose tissue to enhance organismal energy expenditure is considered a promising therapeutic strategy to combat obesity. Here, we report that expression of the p38 MAPK...
8.
Gonzalez-Teran B, Matesanz N, Nikolic I, Verdugo M, Sreeramkumar V, Hernandez-Cosido L, et al.
EMBO J
. 2016 Feb;
35(5):536-52.
PMID: 26843485
Non-alcoholic fatty liver disease (NAFLD) is a major health problem and the main cause of liver disease in Western countries. Although NAFLD is strongly associated with obesity and insulin resistance,...
9.
Lopez-Moreno J, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Buhler K, Costa-Alba P, et al.
Alcohol Clin Exp Res
. 2015 Sep;
39(10):1939-50.
PMID: 26365275
Background: Alcohol binge drinking is one of the most common patterns of excessive alcohol use and recent data would suggest that histone deacetylases (HDACs) gene expression profiling could be useful...
10.
Hatle K, Gummadidala P, Navasa N, Bernardo E, Dodge J, Silverstrim B, et al.
Mol Cell Biol
. 2013 Mar;
33(11):2302-14.
PMID: 23530063
Mitochondria are the main engine that generates ATP through oxidative phosphorylation within the respiratory chain. Mitochondrial respiration is regulated according to the metabolic needs of cells and can be modulated...