Edda Thies
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Explore the profile of Edda Thies including associated specialties, affiliations and a list of published articles.
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21
Citations
1170
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Recent Articles
1.
Matschke J, Hartmann K, Pfefferle S, Wang Y, Valdes P, Thies E, et al.
J Med Virol
. 2024 Jul;
96(7):e29811.
PMID: 39011825
The recent outbreak of monkeypox virus (MPXV) was unprecedented in its size and distribution. Those living with uncontrolled HIV and low CD4 T cell counts might develop a fulminant clinical...
2.
Gromova K, Thies E, Janiesch P, Lutzenkirchen F, Zhu Y, Stajano D, et al.
Cell Rep
. 2023 Jul;
42(7):112743.
PMID: 37418322
Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptors (AMPARs);...
3.
Wang Y, Hartmann K, Thies E, Mohammadi B, Altmeppen H, Sepulveda-Falla D, et al.
Cells
. 2022 Oct;
11(19).
PMID: 36230910
Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of...
4.
Krasemann S, Dittmayer C, von Stillfried S, Meinhardt J, Heinrich F, Hartmann K, et al.
EBioMedicine
. 2022 Aug;
83:104193.
PMID: 35930888
Background: Autopsy studies have provided valuable insights into the pathophysiology of COVID-19. Controversies remain about whether the clinical presentation is due to direct organ damage by SARS-CoV-2 or secondary effects,...
5.
Muhia M, Yuanxiang P, Sedlacik J, Schwarz J, Heisler F, Gromova K, et al.
Commun Biol
. 2022 Jun;
5(1):589.
PMID: 35705737
Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain activity and corresponding behavioral processes remains unclear. Here we show that murine...
6.
Krasemann S, Haferkamp U, Pfefferle S, Woo M, Heinrich F, Schweizer M, et al.
Stem Cell Reports
. 2022 Jan;
17(2):307-320.
PMID: 35063125
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been detected in patients' brain tissues, its entry routes and resulting consequences are not well understood. Here, we show a pronounced...
7.
Lopes A, Hausrat T, Heisler F, Gromova K, Lombino F, Fischer T, et al.
PLoS Biol
. 2020 Sep;
18(8):e3000820.
PMID: 32866173
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [cHSP])...
8.
Lombino F, Muhia M, Lopez-Rojas J, Brill M, Thies E, Ruschkies L, et al.
Sci Rep
. 2019 Nov;
9(1):15940.
PMID: 31685876
Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell division....
9.
Gromova K, Muhia M, Rothammer N, Gee C, Thies E, Schaefer I, et al.
Cell Rep
. 2018 May;
23(9):2705-2717.
PMID: 29847800
Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function,...
10.
Ghiretti A, Thies E, Tokito M, Lin T, Ostap E, Kneussel M, et al.
Neuron
. 2016 Nov;
92(4):857-872.
PMID: 27817978
The dendritic arbor is subject to continual activity-dependent remodeling, requiring a balance between directed cargo trafficking and dynamic restructuring of the underlying microtubule tracks. How cytoskeletal components are able to...