Ed Lein
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Explore the profile of Ed Lein including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Liu I, Cruzeiro G, Bjerke L, Rogers R, Grabovska Y, Beck A, et al.
Cancer Cell
. 2024 Sep;
PMID: 39232581
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, we delineate a...
2.
Agrawal A, Rachleff V, Travaglini K, Mukherjee S, Crane P, Hawrylycz M, et al.
bioRxiv
. 2024 Jun;
PMID: 38915664
Throughout an organism's life, a multitude of complex and interdependent biological systems transition through biophysical processes that serve as indicators of the underlying biological states. Inferring these latent, unobserved states...
3.
Kalhor K, Chen C, Lee H, Cai M, Nafisi M, Que R, et al.
Nat Commun
. 2024 Mar;
15(1):2511.
PMID: 38509069
In situ transcriptomic techniques promise a holistic view of tissue organization and cell-cell interactions. There has been a surge of multiplexed RNA in situ mapping techniques but their application to...
4.
Huang A, Zhou Z, Talukdar M, Miller M, Chhouk B, Enyenihi L, et al.
bioRxiv
. 2024 Jan;
PMID: 38260600
Alzheimer's disease (AD) is an age-associated neurodegenerative disorder characterized by progressive neuronal loss and pathological accumulation of the misfolded proteins amyloid-β and tau. Neuroinflammation mediated by microglia and brain-resident macrophages...
5.
Sorensen S, Gouwens N, Wang Y, Mallory M, Budzillo A, Dalley R, et al.
bioRxiv
. 2024 Jan;
PMID: 38168270
The mammalian brain is composed of diverse neuron types that play different functional roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of transcriptomically-defined cell types,...
6.
Herb B, Glover H, Bhaduri A, Colantuoni C, Bale T, Siletti K, et al.
Sci Adv
. 2023 Nov;
9(45):eadf6251.
PMID: 37939194
The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. To address this, we integrated transcriptomic data from 241,096 cells (126,840 newly generated) in the...
7.
Tian W, Zhou J, Bartlett A, Zeng Q, Liu H, Castanon R, et al.
Science
. 2023 Oct;
382(6667):eadf5357.
PMID: 37824674
Delineating the gene-regulatory programs underlying complex cell types is fundamental for understanding brain function in health and disease. Here, we comprehensively examined human brain cell epigenomes by probing DNA methylation...
8.
Li Y, Preissl S, Miller M, Johnson N, Wang Z, Jiao H, et al.
Science
. 2023 Oct;
382(6667):eadf7044.
PMID: 37824643
Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function remain unclear. Using...
9.
Han X, Guo S, Ji N, Li T, Liu J, Ye X, et al.
Sci Adv
. 2023 Oct;
9(41):eadf3771.
PMID: 37824619
Quantifying neuron morphology and distribution at the whole-brain scale is essential to understand the structure and diversity of cell types. It is exceedingly challenging to reuse recent technologies of single-cell...
10.
Suresh H, Crow M, Jorstad N, Hodge R, Lein E, Dobin A, et al.
Nat Ecol Evol
. 2023 Sep;
7(11):1930-1943.
PMID: 37667001
Enhanced cognitive function in humans is hypothesized to result from cortical expansion and increased cellular diversity. However, the mechanisms that drive these phenotypic innovations remain poorly understood, in part because...