E Van Gyseghem
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Explore the profile of E Van Gyseghem including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
25
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Recent Articles
1.
Deconinck E, Verstraete T, Van Gyseghem E, Vander Heyden Y, Coomans D
J Chromatogr Sci
. 2012 Feb;
50(3):175-83.
PMID: 22337793
The use of chromatographic descriptors as alternative for Caco-2 permeability in drug absorption screening was evaluated. Therefore, retentions were measured on 17 Reversed-Phase Liquid Chromatographic systems, considered to be orthogonal...
2.
Pendela M, Van Gyseghem E, van den Mooter G, Baert L, Rosier J, Hoogmartens J, et al.
J Pharm Biomed Anal
. 2008 Dec;
49(2):508-12.
PMID: 19097719
A liquid chromatographic method was developed to analyse a tablet containing three anti-human immunodeficiency virus (HIV) compounds: lamivudine, zidovudine and a compound with the code name TMC278.HCl. Due to the...
3.
Van Gyseghem E, Deconinck E, Dumarey M, Jimidar M, Sneyers R, Redlich D, et al.
J Chromatogr Sci
. 2008 Nov;
46(9):793-803.
PMID: 19007481
Orthogonal or dissimilar separation systems provide different selectivities and their application can facilitate the development of methods to identify and quantify impurities in a drug substance. Two sets of chromatographic...
4.
Dumarey M, Put R, Van Gyseghem E, Vander Heyden Y
Anal Chim Acta
. 2008 Feb;
609(2):223-34.
PMID: 18261518
Developing an analytical separation procedure for an unknown mixture is a challenging issue. An important example is the separation and quantification of a new drug and its impurities. One approach...
5.
Deconinck E, Ates H, Callebaut N, Van Gyseghem E, Vander Heyden Y
J Chromatogr A
. 2006 Nov;
1138(1-2):190-202.
PMID: 17097093
The use of chromatographic descriptors in QSAR was evaluated. Therefore, retentions were measured on an immobilized artificial membrane system, 2 micellar liquid chromatography systems and 17 orthogonal or disimilar reversed-phase...
6.
Van Gyseghem E, Jimidar M, Sneyers R, De Smet M, Verhoeven E, Vander Heyden Y
J Pharm Biomed Anal
. 2006 Feb;
41(3):751-60.
PMID: 16466886
The classification or characterization of stationary phases based on chromatographic parameters, in general, requires different test solutes/mixtures and several mobile phases. To simplify the classification/characterization of reversed-phase liquid chromatographic columns,...
7.
Van Gyseghem E, Dejaegher B, Put R, Forlay-Frick P, Elkihel A, Daszykowski M, et al.
J Pharm Biomed Anal
. 2005 Dec;
41(1):141-51.
PMID: 16352413
Several chemometric techniques were compared for their performance to determine the orthogonality and similarity between chromatographic systems. Pearson's correlation coefficient (r) based color maps earlier were used to indicate selectivity...
8.
Put R, Van Gyseghem E, Coomans D, Vander Heyden Y
J Chromatogr A
. 2005 Nov;
1096(1-2):187-98.
PMID: 16301080
In order to select chromatographic starting conditions to be optimized during further method development of the separation of a given mixture, so-called generic orthogonal chromatographic systems could be explored in...
9.
Van Gyseghem E, Jimidar M, Sneyers R, Redlich D, Verhoeven E, Massart D, et al.
J Chromatogr A
. 2004 Aug;
1042(1-2):69-80.
PMID: 15296390
To select appropriate stationary phases from the continuously expanding supply of potentially suitable HPLC columns, the properties of 28 frequently applied stationary phases were determined by measuring several chromatographic parameters....
10.
Van Gyseghem E, Crosiers I, Gourvenec S, Massart D, Vander Heyden Y
J Chromatogr A
. 2004 Feb;
1026(1-2):117-28.
PMID: 14763739
Generic orthogonal chromatographic systems might be helpful tools as potential starting points in the development of methods to separate impurities and the active substance in drugs with unknown impurity profiles....