E R Pearson
Overview
Explore the profile of E R Pearson including associated specialties, affiliations and a list of published articles.
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27
Citations
890
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Recent Articles
11.
van Leeuwen N, Nijpels G, Becker M, Deshmukh H, Zhou K, Stricker B, et al.
Diabetologia
. 2012 Mar;
55(7):1971-7.
PMID: 22453232
Aims/hypothesis: In this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the SNP rs11212617 at a locus that includes the ataxia telangiectasia...
12.
Donnelly L, Doney A, Tavendale R, Lang C, Pearson E, Colhoun H, et al.
Clin Pharmacol Ther
. 2010 Dec;
89(2):210-6.
PMID: 21178985
SLCO1B1 gene variants are associated with severe statin-induced myopathy. We examined whether these variants are also associated with general statin intolerance in a large population of patients with type 2...
13.
Steele A, Shields B, Shepherd M, Ellard S, Hattersley A, Pearson E
Diabet Med
. 2010 Jun;
27(2):157-61.
PMID: 20546258
Aims: To investigate all-cause and cardiovascular mortality in subjects with diabetes caused by a mutation in the hepatocyte nuclear factor 1alpha gene (HNF1A). Methods: We identified 39 British families with...
14.
Zhou K, Donnelly L, Burch L, Tavendale R, Doney A, Leese G, et al.
Clin Pharmacol Ther
. 2009 Oct;
87(1):52-6.
PMID: 19794412
Sulfonylureas are metabolized mainly by the cytochrome p450 2C9 (CYP2C9) enzyme. Two CYP2C9 variants--*2 (Arg144Cys) and *3 (Ile359Leu)--are associated with reduced enzyme activity and impaired substrate metabolism. We identified 1,073...
15.
16.
Donnelly L, Morris A, Pearson E
Diabetes Obes Metab
. 2009 Mar;
11(4):338-42.
PMID: 19267712
Aim: Metformin is the most commonly prescribed oral agent used in the treatment of type 2 diabetes. It is effective at reducing glycosylated Haemoglobin (HbA1c) and decreasing microvascular and macrovascular...
17.
Kimber C, Doney A, Pearson E, McCarthy M, Hattersley A, Leese G, et al.
Diabetologia
. 2007 Apr;
50(6):1186-91.
PMID: 17429603
Aims/hypothesis: The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association analysis. We investigated the role...
18.
Singh R, Pearson E, Clark P, Hattersley A
Diabetologia
. 2007 Jan;
50(3):620-4.
PMID: 17216282
Aims/hypothesis: There is strong evidence that maternal diabetes while offspring are in utero results in offspring beta cell dysfunction and diabetes or glucose intolerance. Offspring born to mothers with a...
19.
Castleden H, Shields B, Bingley P, Williams A, Sampson M, Walker M, et al.
Diabet Med
. 2006 Aug;
23(8):834-8.
PMID: 16911619
Aims: A subset of patients who present as if they have Type 2 diabetes have positive pancreatic autoantibodies, and have been referred to as having latent autoimmune diabetes in adults...
20.
Donnelly L, Doney A, Hattersley A, Morris A, Pearson E
Diabet Med
. 2006 Jan;
23(2):128-33.
PMID: 16433709
Aims: In treating Type 2 diabetes (T2DM), UK guidelines recommend metformin in obese and overweight patients, and either sulphonylureas or metformin in normal weight patients. Although other factors influence prescribing...