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E L West

Explore the profile of E L West including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 710
Followers 0
Related Specialties
Cell Biology
General Surgery
Science
Top 10 Co-Authors
J C Sowden
R A Pearson
R R Ali
Y Duran
A J Smith
R E MacLaren
A C Barber
A Gonzalez-Cordero
J W Bainbridge
M Carandini
Published In
Nature
Cell Transplant
Exp Eye Res
Stem Cells
Prog Brain Res
Affiliations
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Recent Articles
1.
Author Correction: Restoration of vision after transplantation of photoreceptors
Pearson R, Barber A, Rizzi M, Hippert C, Xue T, West E, et al.
Nature . 2024 Jun; 631(8019):E1-E2. PMID: 38844680
No abstract available.
2.
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
Pearson R, Gonzalez-Cordero A, West E, Ribeiro J, Aghaizu N, Goh D, et al.
Nat Commun . 2016 Oct; 7:13029. PMID: 27701378
Photoreceptor replacement by transplantation is proposed as a treatment for blindness. Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to the presence of functional photoreceptors within host...
3.
Restoration of vision after transplantation of photoreceptors
Pearson R, Barber A, Rizzi M, Hippert C, Xue T, West E, et al.
Nature . 2012 Apr; 485(7396):99-103. PMID: 22522934
Cell transplantation is a potential strategy for treating blindness caused by the loss of photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult retina and differentiate to...
4.
Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival
West E, Pearson R, Duran Y, Gonzalez-Cordero A, MacLaren R, Smith A, et al.
Cell Transplant . 2012 Feb; 21(5):871-87. PMID: 22325046
Degeneration of the neural retina is the leading cause of untreatable blindness in the developed world. Stem cell replacement therapy offers a novel strategy for retinal repair. Postmitotic photoreceptor precursors...
5.
Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression
Lakowski J, Han Y, Pearson R, Gonzalez-Cordero A, West E, Gualdoni S, et al.
Stem Cells . 2011 Jul; 29(9):1391-404. PMID: 21774040
Retinal degenerative diseases are a major cause of untreatable blindness. Stem cell therapy to replace lost photoreceptors represents a feasible future treatment. We previously demonstrated that postmitotic photoreceptor precursors expressing...
6.
Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina
Pearson R, Barber A, West E, MacLaren R, Duran Y, Bainbridge J, et al.
Cell Transplant . 2010 Jan; 19(4):487-503. PMID: 20089206
Diseases culminating in photoreceptor loss are a major cause of untreatable blindness. Transplantation of rod photoreceptors is feasible, provided donor cells are at an appropriate stage of development when transplanted....
7.
Cell transplantation strategies for retinal repair
West E, Pearson R, MacLaren R, Sowden J, Ali R
Prog Brain Res . 2009 Aug; 175:3-21. PMID: 19660645
Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been...
8.
Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors
West E, Pearson R, Tschernutter M, Sowden J, MacLaren R, Ali R
Exp Eye Res . 2008 Feb; 86(4):601-11. PMID: 18294631
Retinal degeneration is the leading cause of untreatable blindness in the developed world. Cell transplantation strategies provide a novel therapeutic approach to repair the retina and restore sight. Previously, we...