E Izaurralde
Overview
Explore the profile of E Izaurralde including associated specialties, affiliations and a list of published articles.
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57
Citations
5837
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Recent Articles
1.
Behm-Ansmant I, Rehwinkel J, Izaurralde E
Cold Spring Harb Symp Quant Biol
. 2007 Mar;
71:523-30.
PMID: 17381335
microRNAs (miRNAs) represent a novel class of genome-encoded eukaryotic regulatory RNAs that silence gene expression posttranscriptionally. Although the proteins mediating miRNA biogenesis and function have been identified, the precise mechanism...
2.
Herold A, Klymenko T, Izaurralde E
RNA
. 2002 Jan;
7(12):1768-80.
PMID: 11780633
The conserved family of NXF proteins has been implicated in the export of messenger RNAs from the nucleus. In metazoans, NXFs heterodimerize with p15. The yeast genome encodes a single...
3.
Le Hir H, Gatfield D, Braun I, Forler D, Izaurralde E
EMBO Rep
. 2001 Dec;
2(12):1119-24.
PMID: 11743026
The proteins Mago and Y14 are evolutionarily conserved binding partners. Y14 is a component of the exon-exon junction complex (EJC), deposited by the spliceosome upstream of messenger RNA (mRNA) exon-exon...
4.
Gatfield D, Le Hir H, Schmitt C, Braun I, Kocher T, Wilm M, et al.
Curr Biol
. 2001 Nov;
11(21):1716-21.
PMID: 11696332
Dbp5 is the only member of the DExH/D box family of RNA helicases that is directly implicated in the export of messenger RNAs from the nucleus of yeast and vertebrate...
5.
Koffa M, Clements J, Izaurralde E, Wadd S, Wilson S, Mattaj I, et al.
EMBO J
. 2001 Oct;
20(20):5769-78.
PMID: 11598019
The role of herpes simplex virus ICP27 protein in mRNA export is investigated by microinjection into Xenopus laevis oocytes. ICP27 dramatically stimulates the export of intronless viral mRNAs, but has...
6.
Fribourg S, Braun I, Izaurralde E, Conti E
Mol Cell
. 2001 Oct;
8(3):645-56.
PMID: 11583626
TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes (NPCs). We report a structural analysis of the interaction domains of TAP and p15 in a...
7.
Jun L, Frints S, Duhamel H, Herold A, Dotti C, Izaurralde E, et al.
Curr Biol
. 2001 Sep;
11(18):1381-91.
PMID: 11566096
Background: Although X-linked mental retardation (XLMR) affects 2%-3% of the human population, little is known about the underlying molecular mechanisms. Recent interest in this topic led to the identification of...
8.
Le Hir H, Gatfield D, Izaurralde E, Moore M
EMBO J
. 2001 Sep;
20(17):4987-97.
PMID: 11532962
We recently reported that spliceosomes alter messenger ribonucleoprotein particle (mRNP) composition by depositing several proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. When assembled in vitro, this so-called 'exon-exon junction...
9.
Izaurralde E
Cell Mol Life Sci
. 2001 Sep;
58(8):1105-12.
PMID: 11529502
The distinguishing feature of eukaryotic cells is the segregation of RNA biogenesis and DNA replication in the nucleus, separate from the cytoplasmic machinery for protein synthesis. As a consequence, messenger...
10.
Conti E, Izaurralde E
Curr Opin Cell Biol
. 2001 May;
13(3):310-9.
PMID: 11343901
Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) and is mediated by saturable transport receptors that shuttle between the nucleus and cytoplasm. Our understanding of the molecular interactions underlying this...