E David Leonardo
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Explore the profile of E David Leonardo including associated specialties, affiliations and a list of published articles.
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25
Citations
1573
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0
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Recent Articles
1.
Kirshenbaum G, Chang C, Bompolaki M, Bradford V, Bell J, Kosmidis S, et al.
Mol Psychiatry
. 2023 Jul;
28(12):5337-5349.
PMID: 37479778
Adult neurogenesis is reduced during aging and impaired in disorders of stress, memory, and cognition though its normal function remains unclear. Moreover, a systems level understanding of how a small...
2.
Meng Q, Garcia-Garcia A, Dranovsky A, David Leonardo E
Sci Rep
. 2023 Feb;
13(1):3077.
PMID: 36813805
Deficits in arousal and stress responsiveness are a feature of numerous psychiatric disorders including depression and anxiety. Arousal is supported by norepinephrine (NE) released from specialized brainstem nuclei, including the...
3.
Chohan M, Kopelman J, Yueh H, Fazlali Z, Greene N, Harris A, et al.
Mol Psychiatry
. 2022 Jan;
27(3):1515-1526.
PMID: 35058566
Obsessive-compulsive disorder (OCD) is a disabling condition that often begins in childhood. Genetic studies in OCD have pointed to SLC1A1, which encodes the neuronal glutamate transporter EAAT3, with evidence suggesting...
4.
Youssef M, Atsak P, Cardenas J, Kosmidis S, David Leonardo E, Dranovsky A
Sci Rep
. 2019 Mar;
9(1):4120.
PMID: 30858462
Early life stress predisposes to mental illness and behavioral dysfunction in adulthood, but the mechanisms underlying these persistent effects are poorly understood. Stress throughout life impairs the structure and function...
5.
Besnard A, Langberg T, Levinson S, Chu D, Vicidomini C, Scobie K, et al.
Cell Rep
. 2018 Jun;
23(11):3183-3196.
PMID: 29898391
Stress exposure is associated with the pathogenesis of psychiatric disorders, including post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Here, we show in rodents that chronic stress exposure rapidly...
6.
Youssef M, Krish V, Kirshenbaum G, Atsak P, Lass T, Lieberman S, et al.
Hippocampus
. 2018 May;
28(8):586-601.
PMID: 29742815
Environmental exposures during early life, but not during adolescence or adulthood, lead to persistent reductions in neurogenesis in the adult hippocampal dentate gyrus (DG). The mechanisms by which early life...
7.
David Leonardo E, Dranovsky A
Nat Neurosci
. 2017 Nov;
20(12):1657-1658.
PMID: 29184205
No abstract available.
8.
Harris A, Atsak P, Bretton Z, Holt E, Alam R, Morton M, et al.
Neuropsychopharmacology
. 2017 Nov;
43(6):1276-1283.
PMID: 29090682
Historically, preclinical stress studies have often omitted female subjects, despite evidence that women have higher rates of anxiety and depression. In rodents, many stress susceptibility and resilience studies have focused...
9.
Garcia-Garcia A, Meng Q, Canetta S, Gardier A, Guiard B, Kellendonk C, et al.
Cell Rep
. 2017 Feb;
18(5):1144-1156.
PMID: 28147271
Lifelong homeostatic setpoints for mood-related behaviors emerge during adolescence. Serotonin (5-HT) plays an important role in refining the formation of brain circuits during sensitive developmental periods. In rodents, the role...
10.
Garcia-Garcia A, Navarro-Sobrino M, Pilosof G, Banerjee P, Dranovsky A, David Leonardo E
Int J Neuropsychopharmacol
. 2016 Jun;
19(10).
PMID: 27352617
Background: Differences in 5-HT 1A receptor function have been implicated in vulnerability to depression and in response to treatment. Adding 5-HT 1A partial agonists to selective serotonin reuptake inhibitors has...