E C Gordon-Smith
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Explore the profile of E C Gordon-Smith including associated specialties, affiliations and a list of published articles.
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215
Citations
1597
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Recent Articles
11.
Marsh J, Gordon-Smith E
Cytotherapy
. 2002 Aug;
3(3):189-95.
PMID: 12171725
Background: The autoimmune cytopenias encompass the disorders of immune thrombocytopenia purpura (ITP), pure red-cell aplasia (PRCA), autoimmune hemolytic anemia (AIHA), autoimmune neutropenia and various combinations of these conditions. T lymphocytes...
12.
Papadaki H, Gibson F, Psyllaki M, Gordon-Smith E, Marsh J, Eliopoulos G
Eur J Haematol
. 2002 Feb;
67(4):245-51.
PMID: 11860446
Objective: To investigate further the cellular defect responsible for impaired granulopoiesis in severe congenital neutropenia (SCN), we have evaluated bone marrow (BM) stem cell reserve and function and BM stromal...
13.
Scopes J, Ismail M, Marks K, Rutherford T, Draycott G, Pocock C, et al.
Br J Haematol
. 2001 Dec;
115(3):642-52.
PMID: 11736949
Defects in stromal cell function have been demonstrated in a number of aplastic anaemia (AA) patients. Here we have studied a patient with severe AA and abnormal stromal cell function...
14.
Papadaki H, Boumpas D, Gibson F, Jayne D, Axford J, Gordon-Smith E, et al.
Br J Haematol
. 2001 Nov;
115(1):167-74.
PMID: 11722430
The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were investigated. The study was carried out...
15.
Willis F, Marsh J, Bevan D, Killick S, Lucas G, Griffiths R, et al.
Br J Haematol
. 2001 Sep;
114(4):891-8.
PMID: 11564082
We describe 21 patients with severe and life-threatening autoimmune cytopenias resistant to standard immunosuppression who were treated with the monoclonal antibody Campath-1H. Four patients had autoimmune neutropenia, four had autoimmune...
16.
Ismail M, Gibson F, Gordon-Smith E, Rutherford T
Br J Haematol
. 2001 May;
113(3):706-12.
PMID: 11380462
Aplastic anaemia (AA) is a syndrome of haemopoietic failure involving increased apoptosis in stem cells. AA CD34+ cells often have upregulated Fas antigen, but this does not explain the increased...
17.
Killick S, Cox C, Marsh J, Gordon-Smith E, Gibson F
Br J Haematol
. 2001 Feb;
111(4):1164-9.
PMID: 11167757
The mechanism of action of anti-thymocyte globulin (ATG) in aplastic anaemia (AA) is complex. Bone marrow (BM) CD34(+) cells in AA have been shown to be more apoptotic and have...
18.
Cox C, Killick S, Patel S, Elebute M, Marsh J, Gordon-Smith E, et al.
Stem Cells
. 2000 Nov;
18(6):428-34.
PMID: 11072031
It has previously been shown that patients with aplastic anemia (AA) have a stem cell defect both of proliferation and differentiation. This has been shown by long-term bone marrow (BM)...
19.
Papadaki H, Gibson F, Rizzo S, Gordon-Smith E, Marsh J
Blood
. 2000 Oct;
96(9):3272-5.
PMID: 11050013
To investigate whether bone marrow (BM) stem cell compartment and/or BM microenvironment are affected by the immune insult in autoimmune cytopenias (AICs), BM stem cell reserve and function and BM...
20.
Mortazavi Y, Chopra R, Gordon-Smith E, Rutherford T
Eur J Haematol
. 2000 Jul;
64(6):385-95.
PMID: 10901592
Conflicting results have been published on the frequency of clonal patterns of X-chromosome inactivation in female patients with aplastic anaemia. Previous studies have used DNA methylation to measure X-inactivation, but...