E A Hirschowitz
Overview
Explore the profile of E A Hirschowitz including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
175
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Recent Articles
1.
Hirschowitz E, Weaver J, Hidalgo G, Doherty D
Gene Ther
. 2000 Aug;
7(13):1112-20.
PMID: 10918477
Dendritic cells (DC) are highly efficient antigen presenting cells being actively evaluated as vaccine components. A number of studies have shown adenovirus-mediated gene transfer to cultured DCs is feasible and...
2.
Hirschowitz E, Naama H, Evoy D, Lieberman M, Daly J, Crystal R
Cancer Gene Ther
. 1999 Dec;
6(6):491-8.
PMID: 10608345
We hypothesize that adenovirus (Ad) vector-mediated delivery of the human interleukin-2 (IL-2) cDNA (AdIL2) or the murine IL-12 cDNA heterodimer (AdIL12) would produce high concentrations of cytokines in the local...
3.
HARVEY B, Hackett N, El-Sawy T, Rosengart T, Hirschowitz E, Lieberman M, et al.
J Virol
. 1999 Jul;
73(8):6729-42.
PMID: 10400771
Administration of adenovirus (Ad) vectors to immunologically naive experimental animals almost invariably results in the induction of systemic anti-Ad neutralizing antibodies. To determine if the human systemic humoral host responses...
4.
Hirschowitz E, Crystal R
Am J Respir Cell Mol Biol
. 1999 May;
20(5):935-41.
PMID: 10226063
Based on the knowledge that adenovirus (Ad)-mediated expression of the murine gp75 melanoma antigen (Adgp75) will effectively immunize mice against H2-matched B16 melanoma cells, probably via cell- mediated immune mechanisms,...
5.
Hirschowitz E, Leonard S, Song W, Ferris B, Leopold P, Lewis J, et al.
Gene Ther
. 1998 Nov;
5(7):975-83.
PMID: 9813669
Melanocyte differentiation antigens, such as the brown locus protein gp75, are potential biological targets for immunotherapy. We investigated whether expression of the murine gp75 cDNA mediated by an adenovirus (Ad)...
6.
Harrell R, Rajanayagam S, Doanes A, Guzman R, Hirschowitz E, Crystal R, et al.
Circulation
. 1997 Jul;
96(2):621-7.
PMID: 9244235
Background: Restenosis remains a significant problem after balloon angioplasty. Previous studies have demonstrated that recombinant adenoviruses are efficient vectors for gene transfer to the arterial wall and can be used...
7.
Ross H, Hirschowitz E, Russi T, Crystal R, Nawata S, Burt M, et al.
J Surg Res
. 1997 Jun;
70(1):7-11.
PMID: 9228920
Local recurrence of sarcoma is due to residual tumor cells remaining after surgical resection and is associated with decreased survival. We implemented adenoviral-mediated transfer of the herpes simplex thymidine kinase...
8.
Evoy D, Hirschowitz E, Naama H, Li X, Crystal R, Daly J, et al.
J Surg Res
. 1997 Apr;
69(1):226-31.
PMID: 9202675
Gene therapy may allow targeted delivery of tumoricidal drugs to treat pancreatic cancer. Cytosine deaminase (CD) is a bacterial enzyme that converts the nontoxic agent 5-fluorocytosine (5FC) to the active...
9.
Russi T, Hirschowitz E, Crystal R
Hum Gene Ther
. 1997 Feb;
8(3):323-30.
PMID: 9048199
The present study evaluates the hypothesis that delayed-type hypersensitivity (DTH) contributes to the inflammatory reaction observed when high-dose adenoviral (Ad) vectors are administered to a previously immunized animal. Immunocompetent C57BL/6...
10.
Ohwada A, Hirschowitz E, Crystal R
Hum Gene Ther
. 1996 Aug;
7(13):1567-76.
PMID: 8864757
To evaluate the hypothesis that regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene (AdCMV.CD) together with systemic 5-FC could suppress the growth of metastatic colon...