Dylan Kotliar
Overview
Explore the profile of Dylan Kotliar including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
1500
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Recent Articles
1.
Thomas T, Friedrich M, Rich-Griffin C, Pohin M, Agarwal D, Pakpoor J, et al.
Nat Immunol
. 2024 Oct;
25(11):2152-2165.
PMID: 39438660
Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohn's disease (CD) and ulcerative colitis (UC) following adalimumab, an...
2.
Kotliar D, Curtis M, Agnew R, Weinand K, Nathan A, Baglaenko Y, et al.
bioRxiv
. 2024 May;
PMID: 38746317
T-cells recognize antigens and induce specialized gene expression programs (GEPs) enabling functions including proliferation, cytotoxicity, and cytokine production. Traditionally, different classes of helper T-cells express mutually exclusive responses - for...
3.
Kotliar D, Raju S, Tabrizi S, Odia I, Goba A, Momoh M, et al.
Nat Microbiol
. 2024 Feb;
9(3):751-762.
PMID: 38326571
Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here, to...
4.
Normandin E, Triana S, Raju S, Lan T, Lagerborg K, Rudy M, et al.
Cell Genom
. 2024 Jan;
3(12):100440.
PMID: 38169842
Ebola virus (EBOV) causes Ebola virus disease (EVD), marked by severe hemorrhagic fever; however, the mechanisms underlying the disease remain unclear. To assess the molecular basis of EVD across time,...
5.
Brown E, Kales S, Boyle M, Vitti J, Kotliar D, Schaffner S, et al.
Hum Mol Genet
. 2023 Nov;
33(3):270-283.
PMID: 37930192
While genome-wide association studies (GWAS) and positive selection scans identify genomic loci driving human phenotypic diversity, functional validation is required to discover the variant(s) responsible. We dissected the IVD gene...
6.
Benson T, Hibler B, Kotliar D, Avram M
Dermatol Surg
. 2023 Feb;
49(2):149-154.
PMID: 36728065
Background: Keratinocyte carcinoma (KC) is the most common type of nonmelanoma skin cancer. Currently, prophylactic treatment options are limited. Nonablative fractional lasers (NAFL) have received the Food and Drug Administration...
7.
Kotliar D, Colubri A
Bioinformatics
. 2021 Oct;
37(21):3961-3963.
PMID: 34601589
Motivation: Visualizing two-dimensional embeddings (such as UMAP or tSNE) is a useful step in interrogating single-cell RNA sequencing (scRNA-Seq) data. Subsequently, users typically iterate between programmatic analyses (including clustering and...
8.
Botti-Lodovico Y, Nair P, Nosamiefan D, Stremlau M, Schaffner S, Agignoae S, et al.
Viruses
. 2021 Aug;
13(8).
PMID: 34452470
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in...
9.
Kotliar D, Lin A, Logue J, Hughes T, Khoury N, Raju S, et al.
Cell
. 2020 Nov;
183(5):1383-1401.e19.
PMID: 33159858
Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment and outbreak settings. Here, we used single-cell transcriptomics and CyTOF-based single-cell...
10.
Sakabe S, Hartnett J, Ngo N, Goba A, Momoh M, Sandi J, et al.
J Virol
. 2020 Apr;
94(12).
PMID: 32269122
Early and robust T cell responses have been associated with survival from Lassa fever (LF), but the Lassa virus-specific memory responses have not been well characterized. Regions within the virus...