Dustin L Updike
Overview
Explore the profile of Dustin L Updike including associated specialties, affiliations and a list of published articles.
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Citations
745
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Recent Articles
1.
Spaulding E, Updike D
bioRxiv
. 2025 Jan;
PMID: 39763969
Intrinsically disordered arginine-glycine (RG) repeat domains are enriched in multilayered biomolecular condensates such as the nucleolus. nucleolar RG repeats are dispensable for nucleolar accumulation and instead contribute to the organization...
2.
Min H, Spaulding E, Sharp C, Garg P, Jeon E, Miranda Portillo L, et al.
Development
. 2024 Oct;
151(19).
PMID: 39377446
GLH/Vasa/DDX4 helicases are core germ-granule proteins that promote germline development and fertility. A yeast-two-hybrid screen using Caenorhabditis elegans GLH-1 as bait identified BYN-1, the homolog of human bystin/BYSL. In humans,...
3.
Gajjar G, Huggins H, Kim E, Huang W, Bonnet F, Updike D, et al.
bioRxiv
. 2024 Jun;
PMID: 38826235
We studied the function of translation factor eIF4E isoforms in regulating mRNAs in germ cell granules/condensates. Translational control of mRNAs plays an essential role in germ cell gene regulation. Messenger...
4.
Spaulding E, Feidler A, Cook L, Updike D
Nat Commun
. 2022 Nov;
13(1):6585.
PMID: 36329008
The intrinsically disordered RG/RGG repeat domain is found in several nucleolar and P-granule proteins, but how it influences their phase separation into biomolecular condensates is unclear. We survey all RG/RGG...
5.
Rochester J, Min H, Gajjar G, Sharp C, Maki N, Rollins J, et al.
Dev Biol
. 2022 Oct;
492:200-211.
PMID: 36273621
Germ granules harbor processes that maintain germline integrity and germline stem cell capacity. Depleting core germ granule components in C. elegans leads to the reprogramming of germ cells, causing them...
6.
Marnik E, Almeida M, Cipriani P, Chung G, Caspani E, Karaulanov E, et al.
PLoS Genet
. 2022 Jun;
18(6):e1010245.
PMID: 35657999
LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas in Drosophila, help localize the Vasa helicase to the germ...
7.
Phillips C, Updike D
Genetics
. 2022 Mar;
220(3).
PMID: 35239965
The transparency of Caenorhabditis elegans provides a unique window to observe and study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) assemblies specific to the germline cytoplasm,...
8.
Goudeau J, Sharp C, Paw J, Savy L, Leonetti M, York A, et al.
Genetics
. 2021 Mar;
217(4).
PMID: 33693628
We create and share a new red fluorophore, along with a set of strains, reagents and protocols, to make it faster and easier to label endogenous Caenorhabditis elegans proteins with...
9.
Reed K, Svendsen J, Brown K, Montgomery B, Marks T, Vijayasarathy T, et al.
Nucleic Acids Res
. 2019 Dec;
48(4):1811-1827.
PMID: 31872227
Piwi-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) are distinct classes of small RNAs required for proper germline development. To identify the roles of piRNAs and siRNAs in regulating gene...
10.
Updike D
Proc Natl Acad Sci U S A
. 2019 Nov;
116(51):25374-25375.
PMID: 31757856
No abstract available.