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Dukanya Dukanya

Explore the profile of Dukanya Dukanya including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 12
Followers 0
Related Specialties
Biochemistry
Oncology
Biology
Top 10 Co-Authors
Vijay Pandey
Peter E Lobie
Basappa Basappa
Shreeja Basappa
Ganga Periyasamy
Ananda Swamynayaka
Divakar Vishwanath
Tao Zhu
Swamy S Girimanchanaika
Mahendra Madegowda
Published In
Int J Mol Sci
NPJ Precis Oncol
Molecules
Chem Biodivers
ACS Pharmacol Transl Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells
Kim N, Dukanya D, Sethi G, Girimanchanaika S, Yang J, Nagaraja O, et al.
Transl Oncol . 2024 Aug; 49:102101. PMID: 39159553
Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a-hexahydrocyclopenta[e] [1,2]oxazine (FPPO;...
2.
Development of Novel Indazolyl-Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR-2 in Human Breast Cancer Cells
Parameshwaraiah S, Shivakumar R, Xi Z, Siddappa T, Ravish A, Mohan A, et al.
Chem Biodivers . 2024 Jan; 21(3):e202301950. PMID: 38258537
The increased expression of VEGFR-2 in a variety of cancer cells promotes a cascade of cellular responses that improve cell survival, growth, and proliferation. Heterocycles are common structural elements in...
3.
Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer
Tan Y, Chiou Y, Guo H, Zhang S, Huang X, Dukanya D, et al.
NPJ Precis Oncol . 2024 Jan; 8(1):8. PMID: 38200104
Aberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation of downstream BAD is associated with a poor outcome of TNBC. Herein, the phosphorylated to non-phosphorylated ratio of...
4.
Monomerization of Homodimeric Trefoil Factor 3 (TFF3) by an Aminonitrile Compound Inhibits TFF3-Dependent Cancer Cell Survival
Pandey V, Zhang X, Poh H, Wang B, Dukanya D, Ma L, et al.
ACS Pharmacol Transl Sci . 2022 Sep; 5(9):761-773. PMID: 36110371
Trefoil factor 3 (TFF3) is a secreted protein with an established oncogenic function and a highly significant association with clinical progression of various human malignancies. Herein, a novel small molecule...
5.
Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase
Vishwanath D, Girimanchanaika S, Dukanya D, Rangappa S, Yang J, Pandey V, et al.
Molecules . 2022 Feb; 27(3). PMID: 35163965
Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss...
6.
Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells
Girimanchanaika S, Dukanya D, Swamynayaka A, Govindachar D, Madegowda M, Periyasamy G, et al.
Int J Mol Sci . 2021 Oct; 22(20). PMID: 34681659
The design and development of a small molecule named NPB [3-{(4(2,3-dichlorophenyl)piperazin-1-yl}{2-hydroxyphenyl)methyl}-N-cyclopentylbenzamide], which specifically inhibited the phosphorylation of BAD at Ser99 in human carcinoma cells has been previously reported. Herein, the...